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BioResearch

Image: A photomicrograph of a liver biopsy from a patient with alpha-1 antitrypsin deficiency. The PAS with diastase stain shows the diastase-resistant pink globules that are characteristic of this disease (Photo courtesy of Wikimedia Commons).

Diseased Liver Model Facilitates Search for AAT Deficiency Cure

Researchers have developed a new humanized liver mouse model with the mutation that causes alpha-1 antitrypsin deficiency in order to determine whether it is possible to cure the disease by repopulating the defective liver with gene edited healthy cells. More...
02 Nov 2017
Image: Fluorescence microscopy reveals melanoma (red, left; black, right) emerging from melanocyte stem cells (Photo courtesy of Hyeongsun Moon and Andrew White, Cornell University).

Melanocyte Stem Cells and UVB Responsible for Some Cancers

Cancer researchers working with mouse melanoma models have identified a mechanism responsible for the initiation of skin cancer through the interaction of ultraviolet light (UVB) and melanocyte stem cells. More...
01 Nov 2017
Image: The outer protein shell (procapsid) of the herpes simplex virus type 1 (HSV-1) (Photo courtesy of Dr. Bernard Heymann).

Study Highlights Long-Term Continuity of HSV

A team of molecular virologists traced the physical and genetic variations expressed by herpes simplex virus following an infection that had been passed from a father to his son. More...
31 Oct 2017
Image: The yTRAP can be used to create cellular sensors for protein aggregation. The sensor produces fluorescent signals that depend on the protein aggregation state in the cell. In this experiment, three cell types were tested that produce varying signal strength depending on the aggregation of a prion protein. The brightest green for no prion aggregation (bottom), a slightly dimmer green to show a weak presence of prion aggregation (top right) and an even dimmer green signal for a strong prion presence (top left) (Photo courtesy of Dr. Ahmad S. Khalil).

Genetic Tool Monitors and Manipulates Cellular Protein Aggregates

A newly developed genetic tool allows researchers to track the level of protein aggregation in cells, and to a certain extent, manipulate or eliminate the aggregates. More...
30 Oct 2017
Image: If mitophagy or Pac Man eats all the cell\'s mitochondria, then the \"seeds of cancer\" (stem cells) will be able to grow unhindered and develop more malignant tumors (Photo courtesy of the University of Southern California, Keck School of Medicine / Linya Wang).

Loss of p53 Promotes Survival of Cancer Stem Cells

Cancer researchers have found that the cellular cleansing process known as mitophagy is linked to the development and progression of liver cancer. More...
26 Oct 2017
Image: A scanning electron microscope (SEM) image of the Parkinson\'s disease model yeast Saccharomyces cerevisiae (Photo courtesy of Wikimedia Commons).

Modified CRISPR/Cas9 Identifies Genes that Protect against PD

A team of molecular biologists working with a yeast model of Parkinson's disease (PD) used a modified version of the CRISPR/Cas9 genome-editing tool to identify genes that protect against the toxicity of the PD protein alpha-synuclein. More...
25 Oct 2017
Image: A model of the solved protein complex responsible for the selection of antigens (Photo courtesy of AG Tampé).

X-ray Crystallography Explains Immune System Response

A team of German researchers used X-ray crystallography explain a critical step in the immune system's response to foreign proteins by establishing the structure of the critical TAPBPR–MHC I complex. More...
24 Oct 2017
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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