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HTLV I/II抗体的快速自动免疫测定问世

By LabMedica International staff writers
Posted on 05 Nov 2015
一种自动免疫测定可检测捐献的血液和用于日常诊断的样本中抗人T-亲淋巴病毒I或II (HTLV-I/II)的抗体,现已面向血液中心和临床实验室销售。

瑞士巴塞尔罗氏公司的HTLV-I/II免疫测定是为在Elecsys台式分析仪上使用而设计的。这台IVD仪器采用更强的化学发光(ECL)技术,能给出精确而可靠的结果,改进病人护理。

Elecys分析仪使用两种具电化学活性的物质——钌复合体与三丙胺(TPA)。这些试剂参与反应,引起发光。Ruthenium and TPA非同位素,在基本状态非常稳定。只有当作用电压并重复激励受标记的化合物时反应物才开始发射光子。为了启动反应,在工作电极和反电极之间施加电压,生成一个电场,确保反应精确受控并定时。

将含样本和试剂的溶液注入测量细胞,然后进行操作。施加一个磁场,使顺磁珠(涂覆抗原/抗体复合物,由链霉亲和素-生物素固定)与测量细胞表面结合。引入ProCell溶液,以分离免疫测定复合物与游离的粒子并提供TPA,它对ECL反应至关重要。运行一次检验约需18分钟。

罗氏公司诊断部运营总监Roland Diggelmann说:“全球有约2千万人感染HTLV-I/II,许多人不知道自己是携带者。如果检测不到献血者携带的该病毒,感染传播的风险将增大。我公司占有得天独厚的地位,凭借齐全的测定产品线和一体化分子检验与血清检验解决方案,能帮助血液中心提高检验效率。”

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