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为维生素B12缺乏症开发的简易滴血检验

By LabMedica International staff writers
Posted on 28 Jan 2015
科研人员开发的一种新颖方法只需一滴血就能检验维生素B12缺乏症,其灵敏度适用于任何人,包括新生儿。

现在能用指尖采集的一滴血检验维生素B12缺乏症,然后只需点在滤纸构成的检验卡上晾一夜。加拿大温哥华市不列颠哥伦比亚大学(UBC)的Yvonne Lamers教授率领的科研小组开发的干血斑卡分析灵敏度足以测量甲基丙二酸(MMA)的量,它是B12水平的指标。Lamers教授说:“这种微创方法能帮助我们更容易、更方便地测量维生素B12缺乏症,特别是对大批病人样本。我们的方法第一次使得干血斑分析的灵敏度足以检验健康人的维生素B12缺乏症。”

新方法有望加入不列颠哥伦比亚省的新生儿筛查计划,检测该省出生的所有婴儿的可治疗疾病。维生素B12缺乏症如果不能及早检测和治疗,可能导致大脑发育延迟、学习慢和消化问题。治疗包括注射、补充营养品或饮食改变。不列颠哥伦比亚省新生儿筛查计划主任Hilary Vallance说:“我们对Lamers博士的方法感兴趣,它用的血斑卡的灵敏度足以检测和确认维生素B12缺乏症。”加拿大统计局称,大约5%的加拿大成人缺乏维生素B12,20%的人略微缺乏。在发展中国家,缺乏症占人口的50%到80%之高。

该方法还简化了乡村和偏远地区的血样采集和检验,因为那里没有复杂的化验设备。现在印度尼西亚农村的一项科研项目正在使用这种方法。

Schroder TH等人在94名温哥华健康女青年身上测试了这种新方法,并将论文发表于2014年10月1日的《营养杂志》(Journal of Nutrition)。

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