Anti-Inflammatory Drugs May Block Bicarbonate Transport

They then examined the effect of 16 different carbonic anhydrase inhibitors on AE1 transport activity. Among these, 12 were newly reported compounds, two were clinically used nonsteroidal anti-inflammatory drugs (celecoxib and valdecoxib), and two were anticonvulsant drugs (topiramate and zonisamide). The investigators measured transport by following changes of intracellular [Cl−] and pH, using intracellular fluorescent reporter dyes.

Results published in the November 23, 2004, issue of Molecular Membrane Biology revealed that celecoxib and four of the novel compounds significantly inhibited AE1 Cl−/NO3− exchange activity, and that bulkier compounds had greater AE1 inhibitory potency.




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