Autoimmune Diseases Share Inflammatory Mechanism

This induction, which is identical to that previously reported for patients with Grave's disease, is mediated through the insulin-like growth factor-1 receptor (IGF-1R) pathway. Antibodies from individuals without known autoimmune disease fail to elicit this chemoattractant production.

If these findings can be extended to other autoimmune disorders such as multiple sclerosis and lupus, it may be possible to develop a common therapeutic strategy for these conditions. Senior author Dr. Terry J. Smith, a professor in the division of molecular medicine at UCLA said, "It is possible that these findings will allow us for the first time to interrupt the disease process before any lasting damage occurs.”




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