Anti-Inflammatory Drug Spawns Potent Anticancer Drug

Two compounds were generated, OSU-03012 and OSU-03013, that were each 10 times more potent than celecoxib in inducing cancer cell death. These findings were reported in the June 15, 2004, issue of Cancer Research.

"This new agent works by inhibiting a fundamental signaling point in cancer cells, making it potentially effective in a wide range of cancer types,” said senior author Dr. Ching-Shih Chen, professor of pharmacy at Ohio State University. "We also have evidence that it may sensitize leukemia, and breast and lung cancers to conventional chemotherapy.”



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