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Immunology

Image: The ACL AcuStar testing analyzer offers full automation of highly sensitive immunoassays (Photo courtesy of Instrumentation Laboratory).

IgM Antibodies Improve Risk Stratification for Antiphospholipid Syndrome

The antiphospholipid syndrome (APS) is an autoimmune hypercoagulable state and is characterized by thrombosis and/or pregnancy morbidity with the persistent presence of antiphospholipid antibodies (aPL). More...
08 Aug 2018
Image: A photomicrograph of pigmented malignant melanoma in a Papanicolaou stained cytology specimen, (Photo courtesy of Nephron).

Melanoma Biomarkers Predict Checkpoint Blocker Response

The outlook for patients with advanced melanoma has dramatically improved in recent years because of drugs known as immune checkpoint inhibitors, which mobilize the immune system to attack cancer. These drugs block checkpoint molecules that act as brakes on the immune system and unleash immune defenders such as T cells to recognize and attack cancer. More...
02 Aug 2018
Image: The EnVision 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies (Photo courtesy of PerkinElmer).

Homogeneous BTK Occupancy Assay Developed

Bruton’s tyrosine kinase (BTK), a member of the tyrosine kinase expressed in the hepatocellular carcinoma (TEC) family of cytoplasmic protein tyrosine kinases, was initially identified as the pathogenic protein in X-linked agammaglobulinemia, a human primary immune deficiency disease. More...
02 Aug 2018
Image: The SPIFE Touch electrophoresis analyzer (Photo courtesy of Helena).

Urine and Blood Tests Better at Diagnosing Myeloma

Screening and diagnosis of monoclonal gammopathies is generally based on electrophoretic examination of serum and urine proteins, namely serum protein electrophoresis (SPEP)/serum protein immunofixation electrophoresis (SIFE), urine protein electrophoresis (UPEP)/urine protein immunofixation electrophoresis (UIFE), and bone marrow examination. More...
23 Jul 2018
Image: The BN ProSpec chemistry analyzer is a dedicated, compact system that offers a consolidated menu of specialty and routine reagents for reliable plasma protein testing (Photo courtesy of Siemens Healthcare).

Humoral Immunity Disorders Associated with Antibody Deficit

Primary Immunodeficiencies (PID) are a heterogeneous group of diseases and they are rare diseases, but not as rare as once thought, with approximately 400 new PID cases are diagnosed annually in the USA. More...
16 Jul 2018
Image: The Access AccuTnI+3 Reagent is a paramagnetic particle, chemiluminescent immunoassay for the quantitative determination of cardiac troponin I (cTnI) levels in human serum and plasma using the Access 2 Immunoassay System to aid in the diagnosis of myocardial infarction (Photo courtesy of Beckman-Coulter).

Blood Test Predicts Coronary Disease Death Risk

Cardiovascular (CV) disease is a major cause of morbidity and mortality, and is associated with activation of the renin-angiotensin system (RAS). Angiotensin converting enzyme 2 (ACE2) is an endogenous regulator of the renin angiotensin system. More...
05 Jul 2018
Image: A diagram of the protocol for in situ LAMP for Plasmodium-infected red blood cells on hydrophilic-treated cyclic olefin copolymer (COC) plates (Photo courtesy of National Institute of Advanced Industrial Science and Technology).

Loop-Mediated Isothermal Amplification Identifies Malaria Species

Malaria is an infectious disease caused by different species of Plasmodium, of which, five species are reported to infect humans. Since malaria caused by P. falciparum is the most serious, with high mortality, accurate and prompt diagnosis is especially important to effective management. More...
05 Jul 2018
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Immunochromatographic Assay
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Homocysteine Quality Control
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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