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Hematology

Image: A bone marrow aspirate biopsy of a patient with Gaucher Disease; the cytoplasm has wrinkled tissue paper appearance (Photo courtesy of the American Society of Hematology).

Elevated Chitotriosidase Differentially Diagnoses Lysosomal Storage Disorders

Plasma chitotriosidase originates from activated macrophages and is reported to be elevated in many Lysosomal Storage Disorders. Measurement of this enzyme’s activity has been an available tool for monitoring therapy of Gaucher disease. More...
25 May 2016
Image: The Genome Sequencer FLX instrument (Photo courtesy of 454 Life Sciences-Roche).

Gut Microbiome Pretreatment Predicts Chemotherapy-Related Bloodstream Infection

Bacteria are thought to enter the bloodstream through intestinal lesions due to chemotherapy-induced inflammation of the membrane lining the digestive tract. Once the infection begins, patients' own immune systems are depleted and are often unable to fight off the pathogens and antibiotics are often ineffective. More...
19 May 2016
Image: The Mirasol pathogen reduction technology for blood transfusions (Photo courtesy of Terumo BCT).

Blood Transfusions in Malaria Zones Made Safer

Patients, especially children, who undergo blood transfusions in sub-Saharan Africa, are at high risk of transfusion-transmitted malaria. Every year, approximately 214 million people worldwide are infected with acute malaria, the majority of whom are in Africa and the disease is caused by the parasite Plasmodium. More...
03 May 2016
Image: The BD LSR II benchtop flow cytometer (Photo courtesy of Becton Dickinson).

Blood Processing Methods Affect Microparticles Linked To Transfusion Reactions

Specific red blood cell manufacturing methods may be less damaging to cells than others and knowledge of this could help reduce adverse reactions in transfusion recipients and may impact the future of how blood is collected around the world. More...
29 Apr 2016
Image: The Axiovert 40 fluorescent microscope (Photo courtesy of Zeiss).

Novel Method Creates Megakaryocytes From Stem Cells For Transfusion

The production of megakaryocytes (MKs), the precursors of blood platelet, from human pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine. Up to four components can be derived from donated blood: red cells, white cells, plasma and platelets. More...
28 Apr 2016
Image: The Sysmex XS-2000i autoanalyzer (Photo courtesy of Sysmex Corporation).

Elevated Platelet Tests Associated with Severe Heart Disease Risks

As a major component of the blood-vascular axis responsible for preventing hemorrhage, platelets are crucial in the development of ischemic stroke due to its participation in thromboemboli that may initiate the symptoms of stroke.  More...
13 Apr 2016
Image: Electron micrograph of Bartonella henelae, Gram-negative bacteria that causes cat scratch fever (Photo courtesy of the Prokaryotes).

Emerging Blood-Borne Bacteria Found in Blood Donors

Bartonella species cause chronic and intermittent intra-erythrocytic bacteremia and infect endothelial cells of both incidental and natural reservoir hosts. The establishment of chronic, stealth infection is achieved by evasion of innate immune responses.  More...
04 Apr 2016
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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