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BioResearch

Image: Mycobacterium tuberculosis (Mtb) uses environmental pH as a cue to adapt its physiology for survival in macrophages. The phoPR two-component regulatory system functions to sense environmental pH and promote Mtb pathogenesis (Photo courtesy of Michigan State University).

Modifying the Macrophage Microenvironment Reduces Tuberculosis Virulence

The virulence of the bacteria causing latent tuberculosis infections can be reduced by modifying the microenvironment inside the macrophages that host the pathogen.  More...
05 Aug 2015
Image: Structure of the CDA protein (Photo courtesy of Wikimedia Commons).

Salvage of DNA Precursors Is Lethal to Some Cancer Cells

Cancer cells overexpress the enzyme cytidine deaminase, which allows them to recycle inappropriate DNA precursors but renders them susceptible to genetic damage and cell death.   More...
04 Aug 2015
Image: Photomicrograph showing acute myeloid leukemia (AML) cells (Photo courtesy of the University of California, San Diego).

Cell Surface Protein Deletion Blocks AML Growth in Mouse Model

Cancer researchers have found that the cell surface protein tetraspanin3 is required for the development and propagation of the fast-growing and extremely difficult-to-treat blood cancer, acute myelogenous leukemia.  More...
03 Aug 2015
Image: The non-active drug is activated when it becomes localized at a site with excessive inflammation (Photo courtesy of Ben-Gurion University of the Negev).

Chimeric Drug Reduces Local Inflammation Without Causing General Immune Suppression

A novel anti-inflammatory drug is based on a chimeric molecule that avoids general immune suppression by being non-active when injected but is converted into an activate agent by leukocytes concentrated at the site of local inflammation.  More...
02 Aug 2015
Image: New lung cells are continuously created to replace the damaged ones: Lung tissue six weeks after stem cell transplantation (left) and 16 weeks after transplantation (right). Cells that originated in the transplanted stem cells are green, as opposed to the uncolored host lung cells (Photo courtesy of the Weizmann Institute of Science).

Bone Marrow Transplantation Techniques Are Successfully Adapted for Lung Repair

A new approach for repairing the damage caused to lung tissue by diseases such as emphysema, bronchitis, asthma, and cystic fibrosis is based on transplanting embryonic stem cells into damaged lungs that have been conditioned by radiation treatment.  More...
29 Jul 2015
Image: Researchers have generated disease-free stem cells from patients with mitochondrial disease that can be converted into any cell type including neuronal progenitors (left) or heart cells (right). These could potentially be used for future transplantation into patients (Photo courtesy of Salk Institute of Biological Studies).

Methods Developed to Generate Normal Stem Cells from Patients with Mitochondrial Defects

A recent paper described two methods for converting cells from patients with mitochondrial defects into normal pluripotent stem cells that could be induced to differentiate into several different types of tissues.  More...
29 Jul 2015
Image: A new micelle delivery system for the protective polyphenols resveratrol and quercetin (mRQ) may have value in cancer chemotherapy (Photo courtesy of Oregon State University).

Micelles Containing Resveratrol and Quercetin Reverse Doxorubicin Cardiotoxicity

Cancer researchers blocked the toxic effects of the cancer drug doxorubicin by administering it together with the plant antioxidants resveratrol and quercetin.  More...
28 Jul 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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