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BioResearch

Image: Top row: skeletal muscle without dystrophin. Left to right: skeletal muscle nuclei (blue), skeletal muscle (red), missing dystrophin, overlay of all three images to the left. Bottom row: skeletal muscle with restored dystrophin after application of the CRISPR/Cas9 platform. Left to right: skeletal muscle nuclei (blue), skeletal muscle (red), dystrophin (green), Overlay of all three images to the left. Dystrophin appears yellow in overlay image (Photo courtesy of University of California, Los Angeles).

Gene Editing Technique Repairs Mutation Causing Duchenne Muscular Dystrophy

The CRISPR/Cas9 genome editing technique was used to repair the mutation in the dystrophin gene that causes Duchenne muscular dystrophy in induced human pluripotent stem cells derived from DMD patients.   More...
24 Feb 2016
Image: Hereditary deficiency of the enzyme glucocerebrosidase (also known as glucosylceramidase or acid beta-glucosidase) is the cause of Gaucher\'s disease (Photo courtesy of Wikimedia Commons).

Lipid-Induced Immune Activation Responsible for Increased Myeloma Risk in Gaucher's Disease

Analysis of tissue and blood samples from mice and human patients with Gaucher's disease showed that an increased risk for development of myeloma was linked to long-term immune activation by lysophospholipids.  More...
23 Feb 2016
Image: Researchers used a model blood vessel system built into a polymer microchip to study the activity of white blood cells as they were affected by drugs that tend to make them softer, which facilitates their entry into blood circulation (Photo courtesy of Rob Felt, Georgia Institute of Technology).

Physical Considerations Regulate Leukocyte Motion in the Circulatory System

A team of biomedical engineers constructed a model circulatory system within a polymer microchip, creating a tool that enabled them to show that the relative hardness or softness of white blood cell leukocytes determined whether they clung to the edges of blood vessels or circulated freely with the blood.  More...
23 Feb 2016
Image: Structure of LDL (low-density lipoprotein) (Photo courtesy of MP Biomedicals).

LDL-DHA Nanoparticles Selectively Eradicate Liver Tumors in Rat Model System

Uptake of low-density lipoprotein particles loaded with the omega-3 fatty acid docosahexaenoic acid by liver cancer cells resulted in destruction of established tumors in a rat liver cancer model.  More...
22 Feb 2016
Image: T-cell acute lymphoblastic leukemia (T-ALL), a cancer that strikes primarily in childhood, can only survive and grow when sent a signal from neighboring cells called dendritic cells (shown in green) in the tumor\'s near environment (Photo courtesy of the University of Texas, Austin).

Molecular Signals from Neighboring Dendritic Cells Drive Leukemia Growth

Noncancerous cells in the immediate tumor microenvironment supply signals that drive T-cell acute lymphoblastic leukemia growth, and may become attractive therapeutic targets to control the disease.   More...
22 Feb 2016
Image: A neem tree – Azadirachta indica (Photo courtesy of Wikimedia Commons).

Neem Tree Extract Halts Pancreatic Cancer Growth in Mouse Models

Nimbolide, a compound extracted from the leaves of the neem tree  - Azadirachta indica, was shown in culture and mouse models to have potential as a chemotherapeutic agent for the treatment of pancreatic cancer.  More...
21 Feb 2016
Image: Callosal projection neurons (green) are shown in the cerebral cortex (Photo courtesy of Dr. Jessica MacDonald and Dr. Jeffrey Macklis, Harvard University).

Reducing NF-KappaB Signaling Ameliorates Neurological Symptoms in Rett Syndrome Mouse Model

By tracing the molecular pathway linked to the neurological disorder Rett syndrome, researchers have identified molecular pathway that seems to be a potential drug target for alleviating symptoms of the condition.  More...
21 Feb 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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