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BioResearch

Image: Pathological blood vessels (white circles) have abundant CPEB4 expression in cirrhotic tissue (Photo courtesy of the Institute for Research in Biomedicine Barcelona).

Cytoplasmic Polyadenylation Element-Binding Proteins Regulate Pathologic Angiogenesis in Chronic Liver Diseas

A team of molecular biologists has identified a pathway that regulates the pathologic expression of VEGF, the main effector protein in the development of blood vessels, and angiogenesis in chronic liver disease.  More...
03 Jan 2016
Image: The ligand (green) fits like a key to a specific integrin (blue/red) on the surface of the tumor\'s cell membrane (beige) (Photo courtesy of Francesco S. di Leva, Luciana Marinelli / Università di Napoli Federico II).

Modification of Integrin Ligand Receptors May Lead to Personalized Cancer Diagnosis and Treatment

Chemical modification of the guanidine group was used to modify the receptor subtype specificity for the integrin ligand cilengitide, which is an advance that may lead to patient-specific diagnoses and subsequent targeted treatment of tumor cells.  More...
03 Jan 2016
Image: Metastatic cancer cells form nanoscale bridges with endothelial cells lining blood vessels and inject miRNA through these nanobridges to control endothelial cells (Photo courtesy of Dr. Shiladitya Sengupta, Brigham and Women\'s Hospital).

Nanobridges Transport Pro-Metastatic MicroRNAs from Cancer Cells to Surrounding Normal Tissues

Scanning electron microscope images revealed that spreading breast cancer cells generated "nanobridges" to connect to surrounding endothelial cells in order to transfect them with pro-metastatic microRNA molecules.  More...
30 Dec 2015
Image: The micrograph shows a lung cancer cell in which extra copies of the ADAR1 gene are shown in green. Two normal copies of a control gene are shown in red (Photo courtesy of Bellvitge Biomedical Research Institute).

Multiple Copies of RNA Editing Enzyme Gene Promote Lung Cancer Growth

A gene that codes for an enzyme that modulates RNA editing is present in multiple copies in non-small-cell lung cancer cells where they stimulate growth and cell division and indicate a poor prognosis for patients that carry them. More...
30 Dec 2015
Image: Structure of the transcription factor IRF3 (interferon regulatory factor 3) (Photo courtesy of Wikimedia Commons).

Small Molecule Innate Immune System Stimulators Show Promise as Broad-Spectrum Antiviral Drugs

A family of low molecular weight compounds has been identified that activates the innate immune system to stimulate broad-spectrum protection against viral infections.  More...
29 Dec 2015
Image: Brain damage is outlined in red for rats that were treated to block one type of RNA (right), compared to controls (left) (Photo courtesy of Raghu Vemuganti, Suresh Mehta and TaeHee Kim, University of Wisconsin-Madison).

Blocking a Long Noncoding RNA Reduces Stroke Damage in Rat Model

By preventing expression of a long noncoding RNA following induced stroke in a rat model, neurosciences researchers were able to limit damage to the brain and reduce the severity of post-stroke symptoms.  More...
29 Dec 2015
Image: Burkholderia pseudomallei colonies of on Ashdown\'s agar after four days\' incubation showing the characteristic cornflower head morphology (magnified 5x) (Photo courtesy of Wikimedia Commons).

Structure of Bacterial Polysaccharide Synthesizing Enzyme May Lead to New Drugs

A team of molecular microbiologists has determined the mode of action of a bacterial enzyme that is critical to the formation of the organism's protective capsular polysaccharide.  More...
28 Dec 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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