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BioResearch

Image: The photomicrograph shows that a less aggressive tumor turns into a more aggressive tumor when artificially made to increase its manganese superoxide dismutase (MnSOD) levels (Photo courtesy of the National University of Singapore).

Modulation of Redox Environment Increases Breast Cancer Aggressiveness

Cancer researchers have identified an enzyme that promotes the transition of breast tissue from epithelial (non-cancerous) to mesenchymal (metastatic cancer-like) modes during the development of invasive triple negative breast cancer. More...
16 Nov 2016
Image: The Structural model of the galectin-3 (Gal3) protein (Photo courtesy of Wikimedia Commons).

Inhibition of Galactin-3 Reverses Insulin Resistance in Diabetes and Obesity Models

Chemical or genetic inhibition of the protein galectin-3 (Gal3) was shown to reverse insulin resistance and glucose intolerance in mouse models of obesity and diabetes. More...
16 Nov 2016
Image: In the image, a super-enhancer driven cell identity gene (red dot) localizes in close proximity to the nuclear envelope (green) in the nucleus of human primary lung fibroblasts (blue) (Photo courtesy of the Salk Institute for Biological Studies).

Proteins in Cell Nuclear Membrane Actively Influence Gene Expression

A team of cell biologists has brought to light new information as to how proteins in the nuclear membrane act to regulate the expression of genes that determine how a cell functions and what role it plays in the organism. More...
15 Nov 2016
Image: The XLRS is caused by mutations in the retinal protein retinoschisin. The protein plays a crucial role in the cellular organization of the retina, assembling itself to form paired octameric (consisting of eight retinoschisin) rings. The rings each resemble an eight-bladed propeller (Photo courtesy of the University of Manchester).

Report Describes Mechanism Underlying Genetic Eye Disease

The molecular mechanism responsible for the genetic eye disease X-linked Retinoschisis (XLRS), which leads to a type of macular degeneration in which the inner layers of the retina split causing severe loss of vision and gradual blindness, was described in a recent publication. More...
15 Nov 2016
Image: Schematic of a gateway in the nuclear membrane, known as the nuclear pore complex (NPC), and the proteins (shown as spheres) involved in transport and quality control of mRNAs (shown in red). A combination of a multitude of protein-protein interactions enables the cell to distinguish and keep aberrant mRNAs from exiting the nucleus (Photo courtesy of Mohammad Soheilypour, Berkeley National Laboratory).

Messenger RNA Quality Control Mechanism Explained

Genomics researchers have described a mechanism that explains how molecules of messenger RNA (mRNA) are checked for accuracy before being released from the nucleus into the cytoplasm. More...
15 Nov 2016
Image: The structural model of the SIRT2 protein (Photo courtesy of Wikimedia Commons).

Researchers Describe Aggressive Breast Cancer Molecular Mechanism

Cancer researchers have found that SIRT2, a member of the sirtuin family of enzymes, stabilizes Slug, a transcription factor that promotes the development, growth, and spread of basal-like breast cancer. More...
11 Nov 2016
Image: The RNA-protein complex Sm/RNP, which is released from dead cells, stimulates B-cells capable of producing anti-Sm/RNP antibody (anti-Sm/RNP B lymphocytes). The resulting anti-Sm/RNP antibody induces development of systemic lupus erythematosus (SLE) by forming immune complexes together with Sm/RNP (Photo courtesy of the Department of Immunology, Tokyo Medical and Dental University).

Protein Identified Prevents Systemic Lupus Erythematosus

A protein has been identified that functions to prevent the immune system from generating the autoimmune response responsible for lupus erythematosus, a disease associated with inflammation of various organs including kidney, brain, skin, heart, and lung. More...
11 Nov 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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