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Image: Supervised learning facilitates the generation of an STXBP1-specific variant effect predictor, EpiPred. (Jeffrey D. Calhoun et al., Gene-specific machine learning model EpiPred identifies likely pathogenic variants in the epilepsy-related gene STXBP1, Journal of Clinical Investigation (2026). DOI: 10.1172/jci207160)

AI Tool Classifies Pathogenic Variants in Severe Childhood Epilepsy

An AI approach predicts whether genetic variants cause disease, outperforming general tools and helping clarify uncertain epilepsy findings More...
16 Oct 2026
Image Credit: iStock

Noninvasive Cervical Test Detects Endometrial Cancer for Triage

A new cervical methylation test enables noninvasive triage for endometrial cancer. More...
16 Oct 2026
Image: Overview of available modalities in the MSK-IMPACT cohort (n = 52,236 patients), including longitudinal BMI trajectories, serologic laboratory tests, radiology-derived progression annotations and tumor genomic profiling. Human silhouette created in BioRender. (Castillon, V.J., Xie, A.X., Boscenco, S. et al. Nature Medicine (2026). https://doi.org/10.1038/s41591-026-04689-9)

Multimodal Clinical Data Models Predict Cachexia Risk Across Cancers

A new approach integrates routine labs, weight, imaging and genomics to map cachexia and predict patient risk. More...
16 Oct 2026
Image: EndoSign is a non-endoscopic, methylation-based Barrett’s esophagus test using samples collected with an FDA-cleared EndoSign Cell Collection Device (Photo courtesy of Cyted Health)

Molecular Test Detects Barrett’s Esophagus to Guide Endoscopy Referral

A new non-endoscopic methylation test flags Barrett’s esophagus, guiding endoscopy with 90% sensitivity and 86% specificity. More...
16 Oct 2026
Image: The recommendations include extended molecular testing at diagnosis to identify high-risk mutations and guide care. (Image Credit: Adobe Stock)

New Myelofibrosis Guidelines Recommend Expanded Genetic Testing at Diagnosis

Guidelines recommend expanded genetic testing, targeted therapy, selective aspirin use, and early transplant referral in myelofibrosis. More...
16 Oct 2026
Image: The system is designed to measure blood viscoelasticity and density to assess coagulation from clot formation through breakdown in less than 10 minutes.(Image Credit: iStock)

Handheld Point-of-Care Test Aims to Enable Rapid Coagulation Assessment in Trauma

A new point-of-care test is desinged to deliver under-10-minute coagulation assessment from a single drop of blood. More...
16 Oct 2026
Image: The discovery could enable early screening of young children, with the long-term goal of preventing pediatric cancers from developing later in childhood. (Image Credit: Shutterstock)

Blood Antibody Signals May Offer Clues to the Origins of Childhood Cancer

New findings identify blood-based immune markers that may flag increased childhood cancer risk years before diagnosis. More...
16 Oct 2026
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