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Molecular Diagnostics

Image: A histological micrograph showing endometrium with abundant plasma cells, which are diagnostic for chronic endometritis and scattered neutrophils (Photo courtesy of Nephron).

Molecular Diagnostic Tool Developed for Chronic Endometritis

Chronic endometritis is a persistent inflammation of the endometrial mucosa caused by bacterial pathogens. Although chronic endometritis can be asymptomatic, it is found in up to 40% of infertile patients and is responsible for repeated implantation failure and recurrent miscarriage. More...
04 Apr 2018
Image: A graphic comparison of a healthy joint and osteoarthritis (Photo courtesy of European Union Cordis).

New Osteoarthritis Genes Discovered

Almost nine million people in the UK suffer from osteoarthritis, a degenerative joint disease in which a person's joints become damaged, stop moving freely and become painful. Osteoarthritis is the most prevalent musculoskeletal disease and a leading cause of disability worldwide. More...
04 Apr 2018
Image: A diagram of the approach used to evaluate urinary cells; UroSEEK assay is designed to detect urothelial neoplasms that are in direct contact with urine (Photo courtesy of Johns Hopkins Medicine).

Urinary Gene-Based Test Detects Bladder Cancer

Predominantly of urothelial histology, invasive bladder cancer (BC) arises from non-invasive papillary or flat precursors, and many BC patients suffer multiple relapses prior to progression, providing ample lead-time for early detection and treatment prior to metastasis. More...
03 Apr 2018
Image: Since fluid from the Pap test occasionally contains cells from the endometrium or ovaries, scientists found they could detect cancer cells from these organs that are present in the fluid by using different brushes (Photo courtesy of Johns Hopkins University).

Cervical Fluid Test Developed for Gynecological Cancers

Together, endometrial and ovarian cancers account for about 25,000 deaths each year and are the third leading cause of cancer-related mortality in women in the USA. Most of these deaths are caused by high-grade tumor subtypes, which tend to metastasize before the onset of symptoms. More...
03 Apr 2018
Image: In an outbreak of Legionnaires\' disease, finding the exact source as quickly as possible is essential to preventing further infections. Investigators have now developed a rapid test that identifies Legionella pneumophila in less than one hour. The photograph shows the use of the LegioTyper-chip with the MCR microarray analysis platform (Photo courtesy of Jonas Bemetz, Technical University of Munich).

Rapid Detection of Legionella Offered for Commercial Water Systems

A rapid (approximately one hour) DNA microarray-based assay is set to replace classical culture methods for identification of Legionella bacteria in commercial water systems. More...
02 Apr 2018
Image: The friction ridges on a finger (Photo courtesy of Wikimedia Commons).

New Fingerprint Assay Accurately Identifies Users of Heroin and Cocaine

A test protocol based on liquid chromatography-mass spectrometry (LC-MS) analysis accurately detects levels of illegal drugs in a single fingerprint from drug users while eliminating those who had only passive contact with a drug user. More...
02 Apr 2018
Image: The HiSeq2000 instrument used for whole-genome sequencing targeted resequencing, gene expression level detection, DNA methylation profiling, de novo sequencing, metagenomic studies, and ChiP-seq (Photo courtesy of Illumina).

Chromosome Interaction Profiling Reveals Cancer Risk Genes

Breast cancer is a heterogeneous disease with two main subtypes defined by the presence (ER+) or absence (ER−) of the estrogen receptor. Approximately 80% of newly diagnosed breast cancers are ER+ although this proportion varies with age at diagnosis and ethnicity. More...
29 Mar 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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