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BioResearch

Image: The Axio Observer family consists of three stable and modular microscope stands for flexible and efficient imaging (Photo courtesy of ZEISS).

Researchers to Benefit from New Inverted Microscopes

A new inverted microscope platform with enhanced optical characteristics and extended water immersion capability is now available for biotech and other life science researchers. More...
09 Nov 2016
Image: The gene therapy involved inserting a functional copy of the NPC1 gene into mice with the disease; the treated animals were then found to have less severe NPC1 symptoms (Photo courtesy of Darryl Leja, National Institutes of Health/National Genome Research Institute).

Gene Therapy Increases Lifespan of Mice with Niemann-Pick Disease

The potential for treating Niemann-Pick Disease Type C1 with gene therapy was demonstrated in a mouse model of the syndrome. More...
09 Nov 2016
Image: Cytochrome bd-I tagged with Green Fluorescent Protein can be visualized in the membrane of E. coli (Photo courtesy of Dr. Mark Shepherd, University of Kent).

Study Reveals Mechanism Protecting UTI Bacteria from Nitric Acid Damage

A team of molecular microbiologists has identified the enzyme cytochrome bd-I oxidase as promoting urinary tract infections by being of critical importance in protecting E. coli bacteria from the effects of nitric oxide generated by the host's immune response. More...
08 Nov 2016
Image: Individual neuron glowing with bioluminescent light produced by a new genetically engineered sensor (Photo courtesy of the Johnson Lab, Vanderbilt University).

Mutated Luciferase Generates Bright Light for Optogenetics Technique

A recent paper described a novel bioluminescent optogenetic technique that used a potent, mutated form of the enzyme luciferase to follow surges of calcium ions in cultured brain cells. More...
08 Nov 2016
Image: Leukemia cells (green) interact with blood vessels (blue) via the molecule CD98 (Photo courtesy of the University of California, San Diego).

Cell Surface Glycoprotein Critical for Acute Myeloid Leukemia

The cell surface glycoprotein CD98 was identified as a key factor required for growth and spread of acute myeloid leukemia (AML). More...
08 Nov 2016
Image: The heart-on-a-chip is made entirely using multi-material three-dimensional printing (3D) in a single automated procedure, integrating six custom printing inks at micrometer resolution (Photo courtesy of Johan Lind, Disease Biophysics Group, and Lori K. Sanders, Lewis Laboratory, Harvard University).

Novel 3D Printing Technique Installs NIV Sensors in Lab-on-a Chip Devices

A team of biomedical engineers developed an advanced three-dimensional (3D) printing technique to embed noninvasive strain sensors into living tissue as an integral component of organ-on-a-chip devices. More...
04 Nov 2016
Image: A brain section from mouse carrying the dementia-causing P301S mutation in human tau shows accumulation of tau neurofibrillary tangles (in dark brown, left). When Nuak1 levels are decreased by 50% (P301S/Nuak1+/-; right), fewer tau tangles accumulate (Photo courtesy of the Zoghbi Laboratory, Baylor College of Medicine).

Enzyme Identified Stabilizes Tau and Prevents Neurodegenerative Disease

Neurodegenerative disease researchers used three different model systems to screen for and identify a gene able to stabilize levels of tau protein in neurons and prevent it from accumulating in amounts capable of injuring or killing the cells. More...
04 Nov 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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