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BioResearch

Image: A neuron in culture was transduced with a virus that expresses a green fluorescent protein and an inhibitory RNA that causes loss of the DENND5A protein. The neurons where then stained with a marker of neuronal processes in red (Photo courtesy of Peter McPherson Laboratory, Montreal Neurological Institute, McGill University).

Loss of Neuronal Enzyme Underlies Rare Childhood Epileptic Encephalopathy

A recessive mutation causing loss of an enzyme required for neuronal development was shown to underlie a rare form of childhood epileptic encephalopathy. More...
08 Dec 2016
Image: Neutralizing antibodies bind to a structure known as the astrovirus capsid spike domain, which projects from the surface of astrovirus particles. By binding to the spike domain, the antibodies block the virus\'s ability to attach to and infect human cells (Photo courtesy of Walter Bogdanoff, University of California, Santa Cruz).

Crystal Structure Reveals How Neutralizing Antibody Blocks Astrovirus Infection

A team of molecular virologists used X-ray crystallography to establish how a neutralizing antibody bound to the surface of the gastroenteritis-causing astrovirus and blocked its entry into uninfected cells. More...
08 Dec 2016
Image: A scanning electron microscopic (SEM) image of a single human lymphocyte (Photo courtesy of Wikimedia Commons).

MicroRNAs Play a Critical Role in B Cell Maturation

A recent paper highlighted the important role of microRNAs in the maturation of the immune system's B lymphocytes (B cells). More...
07 Dec 2016
Image: A C10 antibody (purple) interacting with the Zika virus coat (green) (Photo courtesy of Victor Kostyuchenko, Duke-NUS Medical School).

Antibody-Zika Virus Interaction Visualized by Cryo-Electron Microscopy

An international team of molecular virologists used advanced cryo-electron microscopy (cryoEM) techniques to visualize how the potent anti-Zika virus antibody C10 acts to prevent the virus from infecting human cells. More...
07 Dec 2016
Image: A representation of the different cell types in the rheumatoid synovium (Photo courtesy of the University of Birmingham).

Two Classes of Fibroblasts Inhabit the Synovial Membrane in RA

Rheumatoid arthritis researchers have identified two distinct classes of synovial fibroblasts (SFs) differentiated by expression of either PDPN (podoplanin) or CD248 (endosialin), which were located within different anatomical compartments of the inflamed synovial membrane. More...
07 Dec 2016
Image: A photomicrograph of a mouse macrophage of extending pseudopodia to engulf two particles, possibly pathogens (Photo courtesy of Wikimedia Commons).

HDL Increases Macrophage Immune Response

While high-density lipoproteins (HDL) protect against atherosclerosis by inhibiting inflammation in the endothelial and smooth muscle cells that comprise the arterial wall, in immune macrophages HDL instead increases the inflammatory response. More...
01 Dec 2016
Image: The neuromuscular junction is the synapse where motor neurons communicate with muscle to initiate voluntary movement. A healthy neuromuscular junction (yellow) is characterized by perfect apposition between the motor neuron (green) and nicotinic acetylcholine receptors on the muscle (red). This synapse is damaged early in ALS, a change believed to contribute the onset and progression of the disease (Photo courtesy of the Virginia Tech Carilion Research Institute).

Faulty Protein Interaction Disrupts Neuromuscular Junctions and Triggers ALS

Humans and mice are protected from developing amyotrophic lateral sclerosis (ALS) by the action of muscle fibers that secrete and concentrate the fibroblast growth factor binding protein 1 (FGFBP1) at neuromuscular junctions. More...
01 Dec 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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