We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Pre-Diagnostic Metabolite Concentrations Related to Cancer Risk

By LabMedica International staff writers
Posted on 25 Jul 2017
Print article
Image: The AbsoluteIDQ p180 kit identifies and quantifies more than 180 metabolites from five different compound classes (Photo courtesy of Biocrates Life Sciences).
Image: The AbsoluteIDQ p180 kit identifies and quantifies more than 180 metabolites from five different compound classes (Photo courtesy of Biocrates Life Sciences).
Prostate cancer is the second most commonly diagnosed cancer in men worldwide, but circulating insulin-like growth factor I is the only established risk factor that is potentially modifiable.

The prospective association between plasma metabolite concentrations and risk of prostate cancer overall, and by time to diagnosis and tumor characteristics, and risk of death from prostate cancer has been investigated. Examination of the metabolome may help identify novel risk factors for prostate cancer.

A large team of scientists collaborating with those at the Nuffield Department of Population Health (Oxford, UK) recruited 153,400 men from 19 centers in eight European countries. At recruitment, detailed information was collected on dietary intake, lifestyle, anthropometry and previous disease, and 139,600 men also gave a blood sample. Histological grade was known for 83.8% of cases and information on tumor stage was available for 61.7% of cases.

All plasma samples (citrate anticoagulant) were assayed using the AbsoluteIDQ p180 Kit. Pre-diagnostic plasma concentrations of 122 metabolites, including acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexose and sphingolipids, were measured using targeted mass spectrometry and compared between 1,077 prostate cancer cases and 1,077 matched controls. A triple quadrupole mass spectrometer was used to quantify the metabolites. The concentration of total prostate-specific antigen (PSA) at baseline was measured and was available for 71.1% of men in the current study, including 764 controls, for whom 489 had a concentration below 1 ng/mL, and 768 cases.

The scientists found seven metabolite concentrations, i.e. acylcarnitine C18:1, amino acids citrulline and trans-4-hydroxyproline, glycerophospholipids PC aa C28:1, PC ae C30:0 and PC ae C30:2, and sphingolipid SM (OH) C14:1, were associated with prostate cancer, but none of the associations were statistically significant after controlling for multiple testing. Citrulline was associated with a decreased risk of prostate cancer. After controlling for multiple testing, 12 glycerophospholipids were inversely associated with advanced stage disease, with risk reduction up to 46% per standard deviation increase in concentration. Death from prostate cancer was associated with higher concentrations of acylcarnitine C3, amino acids methionine and trans-4-hydroxyproline, biogenic amine ADMA, hexose and sphingolipid SM (OH) C14:1 and lower concentration of glycerophospholipid PC aa C42:4.

The authors concluded that several metabolites. C18:1, citrulline, trans-4-hydroxyproline, three glycerophospholipids and SM (OH) C14:1 might be related to prostate cancer. Analyses by time to diagnosis indicated that citrulline may be a marker of subclinical prostate cancer, while other metabolites might be related to etiology. Several glycerophospholipids were inversely related to advanced stage disease. The study was published on July 5, 2017, in the journal BMC Medicine.

Related Links:
Nuffield Department of Population Health

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
HLX
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
Plasma Control
Plasma Control Level 1

Print article

Channels

Molecular Diagnostics

view channel
Image: MOF materials efficiently enrich cfDNA and cfRNA in blood through simple operational process (Photo courtesy of Science China Press)

Blood Circulating Nucleic Acid Enrichment Technique Enables Non-Invasive Liver Cancer Diagnosis

The ability to diagnose diseases early can significantly enhance the effectiveness of clinical treatments and improve survival rates. One promising approach for non-invasive early diagnosis is the use... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.