We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Technopath Clinical Diagnostics - An LGC Company


  Silver Produces reagents for medical laboratory diagnostics, including test systems for the determination of various antibod... read more Featured Products: More products

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
06 Feb 2023 - 09 Feb 2023

Antiphospholipid Antibodies Evaluated in Autoimmune Thyroid Diseases

By LabMedica International staff writers
Posted on 29 Nov 2022
Print article
Image: Antiphospholipid Antibodies Evaluated in Autoimmune Thyroid Diseases (Photo courtesy of VisitHealth limited)
Image: Antiphospholipid Antibodies Evaluated in Autoimmune Thyroid Diseases (Photo courtesy of VisitHealth limited)

Autoimmune thyroid diseases (AITD) is the most common organ-specific autoimmune disease, mainly caused by genetic predisposition, environmental factors and dysfunction in the microbiome.

The main types of AITD are Hashimoto's thyroiditis (HT) and Graves' disease (GD). HT, considered the most common endocrine disorder, is characterized by invasion of the thyroid gland by inflammatory lymphocyte cells. This infiltration induced the destruction and the replacement of follicular tissue leading to hypothyroidism.

Immunologists at the Farhat Hached Hospital (Sousse, Tunisia) carried out a retrospective study that included 195 AITD patients. The inclusion criteria were patients older than 18 years and suffering from HT or GD. Patients with another autoimmune disease associated to AITD were excluded. Sera were consecutively collected between January 2017 and December 2018 from four hospitals in the center of Tunisia. Ninety age-matched healthy blood donors (HBD) served as a control group.

Anti-cardiolipin antibodies (aCL, (IgG, IgA and IgM) were determined by using an enzyme-linked immunosorbent assay (ELISA) (Orgentec Diagnostika, Mainz, Germany). Anti-β2 glycoprotein I antibodies (aβ2GPI, IgG, IgA and IgM) were evaluated by an ELISA (Orgentec Diagnostika) using highly purified human β2GPI. Anti-thyroid peroxidase antibodies (TPO-Ab) and anti-thyroglobulin antibodies (Tg-Ab) were assessed with ELISA kit (Euroimmun, Lübeck, Germany). Human autoantibodies against thyrotropin (TSH) receptor (TRAb) were assessed with an ELISA kit (Euroimmun).

The investigators reported that 154 AITD patients were women and 41 were men. Fifty-six healthy subjects were women and 34 were men. The median age of patients and the control group was 45 and 38.5 years, respectively. The frequency of antiphospholipid (aPL) antibodies was significantly higher in patients with AITD and in patients with HT than in HBD (33.3% versus 11.1%, and 38.1% versus 11.1%). The frequency of aPL in GD was significantly lower than in HT (21.4% versus 38.1%). In patients with HT, aβ2GPI (34.5%) was significantly more frequent than aCL (13.6%). The frequency of aβ2GPI was significantly higher in patients with HT than in healthy population (34.5% versus 11.1%). In HT patients, IgA isotype of aβ2GPI was significantly more common than in healthy blood donors (HBD) and in GD patients (27.3% versus 7.8%, and 27.3% versus 12.5%).

The authors concluded that aβ2GPI and not aCL were frequent in AITD. IgA was the predominant isotype of aβ2GPI and that aβ2GPI-IgA was more frequent in HT than in GD. The study was published on November 25, 2022 in the Journal of Clinical Laboratory Analysis.

Related Links:
Farhat Hached Hospital
Orgentec Diagnostika

Gold Supplier
Microplate Centrifuge & Reader
Lyra MP-Reader II
Clinical Lab Centrifuge
POCT Analyzer
Portable Molecular Test Device

Print article


Molecular Diagnostics

view channel
Image: A novel research study moves the needle on predicting sudden cardiac arrest (Photo courtesy of Pexels)

Newly Identified Protein Biomarkers in Blood Predict Sudden Cardiac Arrest Before it Strikes

Sudden cardiac arrest, or the sudden loss of heartbeat, is a life-threatening heart condition and often fatal. Despite providing an organized emergency medical response, less than 10% of individuals having... Read more


view channel
Image: Medical illustration of Carbapenem-resistant Enterobacteriacea (Photo courtesy of CDC, Stephanie Rossow)

Breakthrough Test Enables Targeted Antibiotic Therapy for Various Enterobacter Species

Bacteria of the Enterobacter genus are considered to be the most dangerous bacteria linked to hospital infections across the world. Some of their representatives demonstrate high resistance to commonly-used... Read more


view channel
Image: Flexible copper sensor made cheaply from ordinary materials (Photo courtesy of University of São Paulo)

Low-Cost Portable Sensor Detects Heavy Metals in Sweat

Heavy metals like lead and cadmium can be found in batteries, cosmetics, food and many other things that have become a part of daily life. However, they become toxic if they accumulate in the human body... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.