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Pathology

Image: An illustration of individual breast cancer tumors (Tumors A–D) with cells in varying differentiation states (shown in different colors) within a tumor (Image courtesy of Yeo SK and Guan J-L / Trends in Cancer).

Single-Cell Diagnostics Advocated for Breast Cancer Subtyping

In an opinion article based their analysis of studies, two medical researchers argue that women diagnosed with breast cancer (BC) would likely benefit from treatment based also on identifying the molecular subtype of different cells within their tumors, in addition to current molecular and histopathology testing of collections of tumor cells. More...
06 Nov 2017
Image: The Cxbladder is a non-invasive, urine-based laboratory test that is accurate, easy to use and clinically validated; it measures gene expression levels of five biomarkers that effectively rule out or detect the presence of bladder cancer (Photo courtesy of Pacific Edge).

Urine-Based Markers for Bladder Cancer Reviewed

The advances in understanding bladder cancer at the molecular and genetic level have led to the identification of detectable and measurable alterations associated with the disease. Given the ease of obtaining voided urine and its direct contact with potentially malignant urothelium, numerous urine-based tumor marker tests have been generated. More...
01 Nov 2017
Image: Histopathology of a retinoma showing abundant fleurettes and sparse cells with eosinophilic cytoplasm. Retinomas share the same genetic origin as retinoblastomas (Photo courtesy of Helen Dimaras, PhD).

Genetic Testing Recommended for Children at Risk for Retinoblastoma

Retinoblastoma is a cancer that starts in the retina at the very back of the eye. It can also spread to other parts of the body, including the brain and bones. There are approximately 350 new cases diagnosed each year in the USA. More...
31 Oct 2017
Image: The histologic appearance of serrated polyps: (A) normal colon mucosa; (B) sessile serrated adenoma with saw tooth appearance of the crypts in the longitudinal cut (Photo courtesy of Dr. Cuatrecasas).

Risk for Colorectal Cancer Linked to Polyps and Adenomas

Most colorectal cancer develops from precursors known as polyps, the most common of which are conventional adenomas. Conventional adenomas often progress to colorectal cancer through an intermediate step called high-risk adenomas. More...
25 Oct 2017
Image: An ocular fundus aspect of retinoblastoma (Photo courtesy of Wikimedia).

Liquid Biopsy for Retinoblastoma Discovered

A new study indicates a proof-of-concept for a safe and effective way to derive genetic profile information from a retinoblastoma tumor without removing the eye. More...
24 Oct 2017
Image: The Synapt G2 high definition mass spectrometer (HDMS) (Photo courtesy of Waters).

Metabolomics Analysis Applied to Investigate MPS

Inborn errors of metabolism (IEM) represent a group of about 500 rare diseases with an overall estimated incidence of 1/2,500. The diversity of involved metabolisms explains the difficulties in establishing their diagnosis. More...
17 Oct 2017
Image: Three-dimensional images showing the complex vascular system in ovarian cancer (left) and bladder cancer (right). Thick vessels are colored red, thin vessels colored blue (Photo courtesy of Nobuyuki Tanaka / Karolinska Institutet).

New 3D App Provides More Accurate Cancer Diagnosis

With further development of light-sheet microscopy based 3D imaging, researchers were able to examine tumor biopsy tissue in more detail than current 2D methods, resulting in improved intratumoral heterogeneity phenotyping and diagnosis of solid tumors. More...
16 Oct 2017
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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