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Pathology

Image: The CellSearch Platform for identification, isolation, and enumeration of circulating tumor cells (Photo courtesy of Menarini Silicon Biosystems).

Liquid Biopsy Detects Cancer across Multiple Biomarkers

Although biomarker-directed therapy is in its infancy in prostate cancer compared to some other tumor types, there is a great need for predictive biomarker testing, and great interest in noninvasive methods. However, comprehensive analysis of patients' cell-free DNA has been limited to date. More...
06 Dec 2018
Image: The NextSeq 550 System delivers the power of high-throughput sequencing with the speed, simplicity, and affordability of a benchtop next-generation sequencing (NGS) system (Photo courtesy of Illumina).

Genes Identified That Predispose People to Chronic Kidney Disease

Chronic kidney disease (CKD) affects 10% to 15% of the population worldwide and is now recognized as the most rapidly increasing contributor to global burden of disease. The costs related to CKD and end-stage renal disease (the terminal manifestation of CKD) are an enormous burden for all healthcare systems around the world. More...
05 Dec 2018
Image: The IMMULITE 1000 system is a small bench top immunoassay analyzer (Photo courtesy of Siemens Healthcare Diagnostics).

Levels of IgA Nephropathy Associated with Disease Severity

IgA nephropathy (IgAN) is the most common cause of primary glomerulonephritis. IgAN is associated with a poor prognosis, about 20% to 40% of patients with IgAN progress slowly to end-stage renal failure 20 to 25 years after diagnosis. More...
03 Dec 2018
Image: The ability to detect cell-free circulating tumor DNA in blood provides the opportunity to develop non-invasive tests to measure tumor burden and detect molecular signatures in tumors that are associated with resistance to therapy (Photo courtesy of Huntsman Cancer Institute).

Sensitive Tumor Detection Uses Cell-Free DNA Methylomes

A combination of "liquid biopsy," epigenetic alterations and machine learning has been used to develop a blood test to detect and classify cancer at its earliest stages. The method holds promise of being able to find cancer earlier when it is more easily treated and long before symptoms ever appear. More...
27 Nov 2018
Image: The Quant-iT high sensitivity PicoGreen double-stranded DNA Assay Kit (Photo courtesy of Invitrogen).

Biomarker Found for Prostate Cancer Treatment Response

Prostate cancer is one of the most common cancers in males and has one of the highest five-year survival rate when diagnosed in the localized stage. When diagnosed in the advanced stage or when a localized tumor relapses after the initial local treatment, the usual procedure is to fight it using male hormone (androgen) deprivation therapy. More...
27 Nov 2018
Image: A diagram of the KidCMP cohort of children with severe cardiomyopathies from the past 21 years who were analyzed genetically (Photo courtesy of Catalina Vasilescu/University of Helsinki).

Genetic Basis of Childhood-Onset Cardiomyopathies Identified

Personalized medicine is one of the goals of the current medical studies, where the understanding of the genetic cause and disease mechanism in each individual will promote tailored forms of treatment. Investigators make an important step in this direction by deciphering genetic causes in children and their implications for treatment decisions. More...
21 Nov 2018
Image: The QIAamp circulating nucleic acid kit (Photo courtesy of Qiagen).

Potential Brain Tumor Liquid Biopsies Developed

Liquid biopsies are fluid samples from patients, for example from the blood or urine, which provide a less invasive way to monitor disease compared to tumor biopsies. A less intrusive test could be hugely beneficial for brain tumors where collecting samples can be difficult and risky for patients. More...
20 Nov 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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