We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

22-Gene Genomic Classifier Validated in Recurrent Prostate Cancer Patients

By LabMedica International staff writers
Posted on 25 Feb 2021
Print article
Image: High-power photomicrograph of ductal adenocarcinoma (Prostate cancer) illustrating tall columnar cells with pale to clear cytoplasm and large ovoid nuclei (Photo courtesy of David J. Grignon, MD).
Image: High-power photomicrograph of ductal adenocarcinoma (Prostate cancer) illustrating tall columnar cells with pale to clear cytoplasm and large ovoid nuclei (Photo courtesy of David J. Grignon, MD).
When prostate cancer has been detected or has returned following initial treatment with surgery, radiation therapy and/or hormone therapy, it is said to be recurrent or relapsed. Treatment of recurrent prostate cancer depends on what treatment a patient has previously received and the extent of the cancer.

Some patients have only a rise in prostate-specific antigen (PSA) level as evidence of recurrent cancer. Other patients will have evidence of recurrent cancer on X-rays or scans. Patients who have prostate cancer that continues to grow despite hormone therapy are referred to as having hormone-refractory prostate cancer (HRPC).

An international team of Oncologists led by those at University of California San Francisco Medical Center (San Francisco, CA, USA) in an ancillary study used Decipher genomic classifier (GC) a 22 gene RNA-based signature (Decipher Biosciences Inc, San Diego, CA, USA) that generated GC scores from samples from a total of 352 men (median [interquartile range] age, 64.5 (60-70) years; 314 White [89.2%] participants) passed microarray quality control and comprised the final cohort for analysis, with median follow-up of 13 years. Patient GC scores were calculated on a continuous scale from 0 (lowest) to 1 (highest). Scores were then classified as low (42%), intermediate (38%), or high (20%) using previously established 0.45 and 0.60 as cutoffs.

The team reported that on multivariable analysis, the GC (continuous variable, per 0.1 unit) was independently associated with distant metastasis (DM) (hazard ratio [HR], 1.17; prostate cancer–specific mortality (PCSM) (HR, 1.39), and overall survival (OS) (HR, 1.17) after adjusting for age, race/ethnicity, Gleason score, T stage, margin status, entry prostate-specific antigen, and treatment arm. Although the original planned analysis was not powered to detect a treatment effect interaction by GC score, the estimated absolute effect of bicalutamide on 12-year OS was less when comparing patients with lower versus higher GC scores (2.4% versus 8.9%), which was further demonstrated in men receiving early salvage radiotherapy (sRT) at a prostate-specific antigen level lower than 0.7 ng/mL (−7.8% versus 4.6%).

Felix Y. Feng, MD, a Professor of Radiation Oncology and first author of the study, said, “Thus, our findings can be relatively quickly incorporated into clinical practice. For patients with prostate cancer recurrences following surgery, I believe that the Decipher test can be helpful to guide decisions regarding who should receive radiation alone or radiation with hormone therapy.”

The authors concluded that the ancillary validation study of the Decipher GC in a randomized trial cohort demonstrated association of the GC with DM, PCSM, and OS independent of standard clinicopathologic variables. These results suggest that not all men with biochemically recurrent prostate cancer after surgery benefit equally from the addition of hormone therapy to sRT. The study was published on February 11, 2021 in the journal JAMA Oncology.

Related Links:
University of California San Francisco Medical Center
Decipher Biosciences Inc


Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
GREENCARE A1c
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
Plasma Control
Plasma Control Level 1

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Molecular Diagnostics

view channel
Image: MOF materials efficiently enrich cfDNA and cfRNA in blood through simple operational process (Photo courtesy of Science China Press)

Blood Circulating Nucleic Acid Enrichment Technique Enables Non-Invasive Liver Cancer Diagnosis

The ability to diagnose diseases early can significantly enhance the effectiveness of clinical treatments and improve survival rates. One promising approach for non-invasive early diagnosis is the use... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.