We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




World's First Fully Integrated Platform for Automated High Molecular Weight DNA Extraction

By LabMedica International staff writers
Posted on 23 May 2023
Print article
Image: The world`s first fully integrated platform for automated high molecular weight DNA extraction (Photo courtesy of One BioMed)
Image: The world`s first fully integrated platform for automated high molecular weight DNA extraction (Photo courtesy of One BioMed)

Long-read sequencing, a third-generation technology, throws light on certain "blind spots" that short-read sequencing methods cannot detect, such as complex structural variants. However, isolating high-quality, high molecular weight (HMW) DNA, which is crucial for long-read sequencing, can be a formidable task. The majority of commercial extraction methods compromise the quality and length of the extracted DNA due to mechanical processes like centrifugation or vortexing, as well as alcohol precipitation. These methods tend to be labor-intensive. Now, a novel technology is revolutionizing nucleic acid extraction with a gentle, yet rapid chemistry-based method that selectively binds, gently clusters, and purifies intact DNA using controlled fluidics. This unique workflow is also non-volatile and does not require ethanol, ensuring convenient shipping and room-temperature storage.

One BioMed (Singapore) has launched the X8 HMW DNA Cartridge Kits for automated extraction of HMW DNA, specifically designed for long-read sequencing and genome assembly. The X8 HMW DNA Cartridge Kits, driven by the OneTouch Instrument, present the first globally automated platform for HMW DNA extraction from an array of samples including bacteria, plants, cell culture, tissue, and Peripheral Blood Mononuclear Cells (PBMCs). The kits contain all necessary reagents.

The Xceler8 Platform guarantees consistent and reproducible extraction of HMW DNA up to 2 Mb range from diverse sample types across different users. The purified HMW DNA is fit for a variety of downstream applications including long-read sequencing and de novo genome assembly. Thanks to the flexibility of random access, the Xceler8 Solution can run multiple protocols at the same time and efficiently process up to 8 samples within an hour. This fully integrated, plug-and-play automation system is perfect for labs seeking a highly flexible and consistent method of HMW DNA extraction from a wide variety of sample types.

"We are excited to launch the new X8 HMW DNA Cartridge Kit." said Dr.Mi Kyoung Park, Founder & CEO of One BioMed. "This Kit extends the workflow and performance advantages of the novel Xceler8 Technology, enabling scientists to efficiently extract HMW DNA from a variety of samples, for various downstream applications."

Related Links:
One BioMed 

Gold Member
Flocked Fiber Swabs
Puritan® Patented HydraFlock®
Verification Panels for Assay Development & QC
Seroconversion Panels
New
Alpha-Fetoprotein Reagent
AFP Reagent Kit
New
Blood Gas and Chemistry Analysis System
Edan i500

Print article

Channels

Clinical Chemistry

view channel
Image: QIP-MS could predict and detect myeloma relapse earlier compared to currently used techniques (Photo courtesy of Adobe Stock)

Mass Spectrometry-Based Monitoring Technique to Predict and Identify Early Myeloma Relapse

Myeloma, a type of cancer that affects the bone marrow, is currently incurable, though many patients can live for over 10 years after diagnosis. However, around 1 in 5 individuals with myeloma have a high-risk... Read more

Immunology

view channel
Image: The cancer stem cell test can accurately choose more effective treatments (Photo courtesy of University of Cincinnati)

Stem Cell Test Predicts Treatment Outcome for Patients with Platinum-Resistant Ovarian Cancer

Epithelial ovarian cancer frequently responds to chemotherapy initially, but eventually, the tumor develops resistance to the therapy, leading to regrowth. This resistance is partially due to the activation... Read more

Technology

view channel
Image: Ziyang Wang and Shengxi Huang have developed a tool that enables precise insights into viral proteins and brain disease markers (Photo courtesy of Jeff Fitlow/Rice University)

Light Signature Algorithm to Enable Faster and More Precise Medical Diagnoses

Every material or molecule interacts with light in a unique way, creating a distinct pattern, much like a fingerprint. Optical spectroscopy, which involves shining a laser on a material and observing how... Read more

Industry

view channel
Image: The collaboration aims to leverage Oxford Nanopore\'s sequencing platform and Cepheid\'s GeneXpert system to advance the field of sequencing for infectious diseases (Photo courtesy of Cepheid)

Cepheid and Oxford Nanopore Technologies Partner on Advancing Automated Sequencing-Based Solutions

Cepheid (Sunnyvale, CA, USA), a leading molecular diagnostics company, and Oxford Nanopore Technologies (Oxford, UK), the company behind a new generation of sequencing-based molecular analysis technologies,... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.