New NGS Solutions Provide Powerful Tool for Myeloid Research with Highly Efficient Workflow

OGT (Oxford, UK), a Sysmex Group (Kobe, Japan) company, has launched several new solutions to support its growing next-generation sequencing (NGS) portfolio. These include the SureSeq Myeloid Plus panel, which has been designed to detect aberrations in genes implicated in a variety of Myeloid disorders. Additionally, OGT has also launched a new improved library preparation workflow - the OGT Universal NGS Complete Workflow, compatible with its hematology, inherited and rare disease NGS panels - significantly reducing hands-on time and complemented by updated Interpret NGS Analysis software.

The SureSeq Myeloid Plus panel is the most recent addition to OGT’s hematology NGS portfolio. Having been meticulously designed along-side leading cancer experts, the new panel is able to detect a comprehensive range of aberrations including SNVs, indels, ITDs and PTDs within 49 genes. These genes cover those associated with myeloid disorders including acute myeloid leukemia, myeloproliferative neoplasms and myelodysplastic syndrome among others. Thanks to OGT’s vast expertise in bait design, the Myeloid Plus panel delivers unparalleled coverage uniformity for low frequency variants, even in difficult-to-sequence AT/GC rich regions and challenging regions covering ITDs and PTDs, which are common somatic variants in acute myeloid leukemia (AML) often associated with poor prognosis and an aggressive form of the disease. The power of the Myeloid Plus panel stands testament to the benefits of hybridization capture over PCR enrichment for unrivalled levels of sensitivity and uniformity of coverage.

To support researchers using the SureSeq Myeloid Plus panel, and all of OGT’s SureSeq hematology and CytoSure NGS panels, the new Universal NGS Complete Workflow has been developed. By reducing the number of clean-up steps and QC requirements, library preparation can be completed in just four and a half hours, with a 40% saving of hands-on time. By combining several steps, and introducing sample pooling, the reduced workflow complexity not only decreases the potential for error, but also saves on plastic waste and costs.

Compared to the previous SureSeq workflow, the updated version requires no additional expensive laboratory equipment, making the process much more amenable to automation, and therefore ready for the future. To supplement this new and improved workflow, OGT’s renowned Interpret NGS Analysis software (V3.5) has been upgraded with improvements in CNV interpretation, annotation, visualization and sample data import and display. Unlike many other NGS providers, OGT provides complimentary NGS software with its NGS panels, demonstrating the company’s commitment to sharing technology, and technical expertise to support NGS research around the globe.

“At OGT, we are experts in delivering high efficiency NGS workflows with best-in-class gene panels, software, and library preparation solutions,” said Adrian Smith, Chief Executive Officer of OGT. “Thanks to our unmatched expertise in bait design, and through partnering with leading cancer experts, we have developed a powerful tool for myeloid research with a highly efficient workflow. This enables clinical researchers to quickly and confidently detect all relevant variants in one simple assay. NGS is a key area of expertise for OGT, and we have exciting plans and possibilities for the future.”

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Sysmex Group

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