We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App

Sensitive, Reusable and Rapid Diagnostic Platform to Detect Multiple Pathogens

By LabMedica International staff writers
Posted on 15 Jun 2023
Print article
Image: The G-MAB library contains more than 10 quadrillion (1016) distinct antibody sequences (Photo courtesy of Sorrento)
Image: The G-MAB library contains more than 10 quadrillion (1016) distinct antibody sequences (Photo courtesy of Sorrento)

The development timeline for current rapid testing diagnostic devices (RTDs) is very lengthy, and their clinical sensitivity also tends to be low. Now, a new diagnostic platform is currently under development for rapid and sensitive detection of proteins and other biomolecules, thereby enhancing existing RTDs.

Sorrento Therapeutics (San Diego, CA, USA) and its wholly owned subsidiary, Virex Health (Boston, MA, USA) are jointly developing a highly sensitive, cost-effective diagnostic platform that is adaptable for various pathogens. This initiative harnesses Sorrento's expertise in rapidly selecting and producing highly specific antibodies from its proprietary G-MAB library that target viral and bacterial antigens. This process is combined with Virex’s novel chemical detection approach and utilizes the existing infrastructure of the glucometer industry. Sorrento’s proprietary G-MAB technology utilizes RNA transcription to amplify antibody variable domains from over 600 donors. Detailed analysis of deep sequencing DNA data reveals that the G-MAB library comprises over 10 quadrillion (1016) unique antibody sequences, making it one of the largest fully human antibody libraries in the biopharmaceutical industry.

Virex’s proprietary technology enables electrochemical detection of bioanalytes (such as viruses, proteins, and small molecules), which employs the same electronic devices required in reusable glucometers. The test strip chemistry has been reconfigured by Virex to detect pathogens. The aim is to cater to the needs of rapid detection for biodefense and preparation for emerging infectious diseases. Both Sorrento and Virex aim to provide a rapid, sensitive, accurate, and scalable diagnostic that can be swiftly deployed to combat an imminent or recurring threat.

“Once the diagnostic platform is developed, our unique approach can be quickly transferred to other pathogens and deployed when needed on a large scale,” said Scott Schaus, Ph.D., Co-founder and Chief Technology Officer for Virex Health.

Related Links:
Sorrento Therapeutics
Virex Health

Platinum Supplier
Automatic Nucleic Acid Workstation
Gold Supplier
D-Dimer Test
Epithod 616 D-Dimer Kit
Monkeypox Virus Test
QuantiVirus MPXV Test Kit
Hepatitis B Virus Test

Print article


Clinical Chemistry

view channel
Image: The new assays are designed to run on the B•R•A•H•M•S KRYPTOR compact PLUS clinical chemistry analyzer (Photo courtesy of Thermo Fisher)

Breakthrough Immunoassays to Aid in Risk Assessment of Preeclampsia

Preeclampsia is a life-threatening blood pressure condition that can arise during pregnancy and the postpartum phase. This severe pregnancy complication is a primary cause of maternal and fetal mortality... Read more

Molecular Diagnostics

view channel
Image: A CRISPR technology-based diagnostic test detects MPXV in clinical samples with acute precision (Photo courtesy of 123RF)

Powerful Diagnostic Tool Accurately Detects Monkeypox Virus Faster Than Any Method

At present, testing for the monkeypox virus (MPXV) is done mainly in centralized labs, and it can take days to get results due to location and logistical issues. Now, researchers have leveraged cutting-edge... Read more


view channel
Image: The US FDA has cleared HemoScreen point of care CBC for direct capillary sampling (Photo courtesy of PixCell Medical)

Point of Care CBC Analyzer with Direct Capillary Sampling Enhances Ease-of-Use and Testing Throughput

The world’s only 5-part differential Complete Blood Count (CBC) analyzer that is FDA-cleared, CE-marked, and TGA-approved for point-of-care use has now been granted FDA 510(k) clearance for direct capillary... Read more


view channel
Image: Immune cells present long before infection predict flu symptoms (Photo courtesy of Shutterstock.com)

Single Blood Draw to Detect Immune Cells Present Months before Flu Infection Can Predict Symptoms

For decades, if not centuries, scientists have struggled to solve the mystery of why certain individuals fall ill to infections while others remain unaffected. In an impressive development, researchers... Read more


view channel
Image: The Tasso+ device has received CE Mark certification (Photo courtesy of Tasso)

Groundbreaking Blood Lancing Device Obtains Microliter Capillary Whole Blood Samples Painlessly

A convenient, virtually pain-free blood lancet that collects whole liquid blood samples has received CE Mark designation, making the patient-centric, high-volume blood collection solution available in... Read more


view channel
Image: A new electrochemical device can quickly and inexpensively identify people at greatest risk for osteoporosis (Photo courtesy of ACS Central Science, 2023)

Electrochemical Device Identifies People at Higher Risk for Osteoporosis Using Single Blood Drop

With the global increase in life expectancy, the incidence of age-related conditions like osteoporosis is increasing. Osteoporosis, affecting around 200 million individuals worldwide, has a higher incidence... Read more


view channel
Image: The global fully automatic electrolyte analyzers market is projected to reach close to USD 0.77 billion by 2032 (Photo courtesy of 123RF)

Global Fully Automatic Electrolyte Analyzers Market Driven by Surge in Demand for Point-of-Care Testing

Fully automatic electrolyte analyzers can measure the levels of electrolytes in various bodily fluids like blood and plasma. Electrolytes are ions that have an electrical charge and are essential for multiple... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.