Compound Prevents Breast Cancer in Mice

Called Compound 003, the compound prolonged cancer-free survival in transgenic mice that otherwise invariably develop HER2-positive metastatic breast cancer. The compound is a novel cytotoxic nucleoside analog and was well tolerated in both mice and rats without toxicity.

The research results were published in the November 2004 issue of the international medical journal Arzneimittelforschung. Women with HER2-positive breast cancer have a greater risk for recurrence of their breast cancer and an increased risk of mortality. Roughly 40,000 women in the United States alone die each year from breast cancer.




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Parker Hughes