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Pathology

Image: A histopathology of high-grade cervical intraepithelial neoplasia CIN 3. There is severe dysplasia that involves more than 2/3 of the epithelium, and may involve the full thickness. This lesion may sometimes also be referred to as cervical carcinoma in situ (Photo courtesy of Dr. Sean Kavanagh).

Persistent HPV Infection Raises Risk of Anogenital Cancers

Women with a history of severe cervical intraepithelial neoplasia, a precancerous condition of the cervix that arises from infection with the human papillomavirus, have a long-term increased risk of developing anal, vulvar, and vaginal cancer. More...
21 Jul 2016
Image: The Odyssey CLx scanner for Western Blot analysis (Photo courtesy of LiCor).

Parkinson's Disease Biomarker Found in Urinary Samples

A biomarker helps physicians predict, diagnose or monitor disease, because the biomarker corresponds to the presence or risk of disease, and its levels may change as the disease progresses. More...
20 Jul 2016
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Image: In benign tissue next to a prostate tumor, the orientation of prostate glands, tends to be more uniform in those at low risk for biomedical recurrence but disordered among those at high risk (Photo courtesy of Case Western Reserve University).

Benign Tissue Structural Features Predict Risk of Prostate Cancer Recurrence Following Surgery

A preliminary study found that evaluation of a collection of structural features observed in normal tissues surrounding a prostate tumor was a better predictor of risk of recurrence of the cancer following surgical removal of the tumor by radical prostatectomy (RP). More...
18 Jul 2016
Image: An invasive adenocarcinoma (the most common type of colorectal cancer). The cancerous cells are seen in the center and at the bottom right of the image (blue). Near normal colon-lining cells are seen at the top right of the image (Photo courtesy of Wikimedia Commons).

Detection of Circulating Tumor DNA Predicts Colon Cancer Recurrence

A team of American and Australian cancer researchers has demonstrated that circulating fragments of tumor DNA (ctDNA) could serve as a biomarker for identifying patients with high risk of recurrence of colon cancer. More...
18 Jul 2016
Image: According to new research, a blood test that leads to donor hearts being rejected may not effectively predict whether a heart transplant will succeed or fail (Photo courtesy of the AMA).

Heart Transplantation Recipients Unaffected by Donor Troponin Levels

Many transplant centers routinely reject hearts if the donor’s blood test reveals elevated levels of troponin I, a protein found in heart muscle that enters the bloodstream when there is a heart attack or other heart muscle damage. Donors with previous heart disease are automatically excluded. More...
14 Jul 2016
Image: The E220 focused-ultrasonicator for DNA fragmentation (Photo courtesy of Covaris).

Genetic Causes of Bowel Cancer Clarified

Colorectal cancer (CRC) displays a complex pattern of inheritance and it is postulated that much of the missing heritability of CRC is enshrined in high-impact rare alleles, which are mechanistically and clinically important. More...
14 Jul 2016
Image: An adult deer tick Ixodes scapularis. Lyme disease is caused by Borrelia bacteria and transmitted to humans upon the bite of infected ticks of the genus Ixodes (Photo courtesy of Scott Bauer, Agricultural Research Service of USDA / Wikimedia).

Likely Flaws Uncovered for LM-Method for Lyme Disease Detection

According to a new study, the recently developed modified microscopy technique “LM-method” of examining blood samples to help diagnose Lyme disease (and babesiosis) – is unable to distinguish infected patients from healthy controls, yielding many false-positive results. More...
12 Jul 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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