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Pathology

Image: A diagram of colon cancer and a colon polyp; not all polyps are cancerous, but nearly all colorectal cancers begin as a polyp (Photo courtesy of Jefferson Health).

Colorectal Cancer Clues Provided by Polyp Profiles

Colorectal cancer (CRC) develops through progressive accumulation of alterations beginning with abnormal growth of the colon epithelium, which over time can transform to an adenomatous polyp and then cancer. More...
02 Mar 2018
Image: An histology of an early post-transplant allograft biopsy showing a glomerulus with prominent neutrophil infiltration. A few neutrophils are also seen in the interstitium. These findings can be seen in early stages of hyperacute rejection (Photo courtesy of the University of Pittsburgh Medical Center).

Kidney Biopsy Profiles Predict Delayed Graft Function

The probability of renal graft failure can be assessed for donor kidney biopsies through histological analyses; the potential for delayed graft function is not as easily determined by morphology alone, but could potentially be aided by molecular analysis. More...
28 Feb 2018
Image: A cross-section of a healthy brain compared with a brain from a patient with Alzheimer’s disease (Photo courtesy of the Alzheimer’s Association).

Immune System Dysfunction May Occur Early in Alzheimer’s Disease

Inflammatory markers have been shown to predict neurocognitive outcomes in aging adults; however, the degree to which peripheral markers mirror the central nervous system remains unknown. More...
21 Feb 2018
Image: An immunohistochemistry of anti-Alpha-Fetoprotein (AFP) antibody on liver tissue from a human hepatocellular carcinoma patient (Photo courtesy of Arigo Biolaboratories).

Blood Test Plus Ultrasound Enhances Liver Cancer Detection

While the incidence of most cancers is decreasing in the USA the incidence of liver cancer has increased by 2.7% a year over the last 10 years, which is estimated at about 40,700 new cases of liver cancer that will be diagnosed in the USA in 2018. More...
20 Feb 2018
Image: The FLUOstar Omega multi-mode microplate reader with six detection modes (Photo courtesy of BMG Labtech).

Molecular Test Adapted for Parkinson’s and DLB

Parkinson’s disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB) (or Lewy body dementia) are called α-synucleinopathies due to the abnormal accumulation of aggregates of a protein called α-synuclein (αSyn) in the brain. More...
20 Feb 2018
Image: The HiSeq X whole genome sequencing system (Photo courtesy of Illumina).

Genomic Sequencing Augments Diagnosis of Lymphoid Cancer

Lymphoid cancers include diffuse large B-cell lymphomas (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL). In recent years, several sequencing-based assays have been developed, but their clinical applicability and utility for patients with specific mutations still needs to be verified. More...
19 Feb 2018
Image: A histopathology of esophageal squamous cell carcinoma with keratin pearl formation (Photo courtesy of Dr. Dharam Ramnani, MD).

Esophageal Cancer GWAS Leads to Risk Variants

Genome-wide association studies have identified common variants associated with risk of esophageal squamous cell carcinoma; however, these common variants cannot explain all heritability of esophageal cancer. More...
15 Feb 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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