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Immunology

Image: Histopathology of ovarian serous papillary borderline tumor, intracystic, without surface cortical involvement (Photo courtesy of Brown University).

Prognostic Biomarker Candidates Identified for Ovarian Cancer

Two independent classes of novel candidate prognostic markers for ovarian cancer have been identified advancing efforts to develop targeted therapies for the disease.  More...
25 Nov 2014
Image: The MRX II microplate reader (Photo courtesy of Dynex Technologies).

Prognostic Biomarker Found for Post-Chemotherapeutic Relapse in Visceral Leishmaniasis

The effective clinical management, chemotherapy and control of the transmission of visceral leishmaniasis are largely dependent on early and unequivocal diagnosis as without effective chemotherapy symptomatic VL is usually fatal.  More...
05 Nov 2014
Image: Immunohistochemistry of lung tissue positive for anaplastic lymphoma kinase in non-small-cell lung cancer (Photo courtesy of Ventana Medical Systems).

Anaplastic Lymphoma Kinase Immunohistochemistry Compares with FISH Testing

The detection of anaplastic lymphoma kinase-gene rearrangements in non–small-cell lung cancer is mainly performed by fluorescence in situ hybridization.  More...
05 Nov 2014
Image: PAR Cyflow-Space Software (Photo courtesy of Sysmex PARTEC)

Flow Cytometry Rapidly Determines Specific Interleukin-6 Activity

The measurement of the specific activity of a given cytokine often requires a time-consuming and tedious bioassay based upon its effect on the proliferation, chemotaxis, or toxicity of a factor-dependent cell line.  More...
29 Oct 2014
Image: Immunofluorescence staining pattern of ANCA using FITC conjugate demonstrates presence of antineutrophil cytoplasmic antibodies (ANCA). Top left - PR3 antibodies on ethanol-fixed neutrophils showing a cytoplasmic ANCA pattern. Bottom left - PR3 antibodies on formalin-fixed neutrophils showing a cytoplasmic ANCA pattern. Top right - MPO antibodies on ethanol-fixed neutrophils showing a perinuclear ANCA pattern. Bottom right - MPO antibodies on formalin-fixed neutrophils showing a cytoplasmic ANCA pattern (Photo courtesy of  Wikimedia Commons).

Monitoring ANCA Levels Helps Predict Relapse of Systemic Vasculitis in Patients with Kidney Involvement

Repeated measurement of levels of anti-neutrophil cytoplasmic antibodies predicts likelihood of relapse in patients suffering from systemic vasculitis with kidney involvement.  More...
28 Oct 2014
Image: An enzyme-linked immunosorbent assay (ELISA) kit for dengue virus NS1 antigen (Photo courtesy of Diagnostic Automation Inc.).

Diagnostic Test Kits for Dengue Virus Detection Evaluated

Laboratory diagnosis of dengue with a single serum specimen obtained during the acute phase of the illness requires tests to detect immunoglobulin M antibodies to Dengue virus or the virus genome.  More...
28 Oct 2014
Image: The API 5000 triple quadruple mass spectrometer (Photo courtesy of AB SCIEX).

Serum Prostate-Specific Antigen Measured by Tandem Mass Spectrometry

Prostate-specific antigen is a widely used blood test for detection and monitoring of prostate disease and many clinicians assume that all test methods produce essentially the same results, though differences do exist.   More...
23 Oct 2014
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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