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Immunology

Image: The FLUOstar Omega multi-mode microplate reader with six detection modes (Photo courtesy of BMG Labtech).

Molecular Test Adapted for Parkinson’s and DLB

Parkinson’s disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB) (or Lewy body dementia) are called α-synucleinopathies due to the abnormal accumulation of aggregates of a protein called α-synuclein (αSyn) in the brain. More...
20 Feb 2018
Image: Immunohistochemistry of MLH-1 (M1) Mouse Monoclonal Primary Antibody which is used to qualitatively identify human DNA mismatch repair (MMR) protein MLH1, expressed in the nucleus of normal proliferating cells. Loss of MLH1 is associated with colorectal and other cancers (Photo courtesy of Roche Tissue Diagnostics).

Colorectal Cancer Immunohistochemistry Panel Launched

The global burden of colorectal cancer is expected to increase by 60% to more than 2.2 million new cases and 1.1 million deaths by 2030. Increasingly, guidelines are recommending universal screening of all newly diagnosed colorectal cancers for Lynch syndrome. More...
13 Feb 2018
Image: Depiction of circulating tumor cells detaching from a primary tumor and circulating through the bloodstream (Photo courtesy of CellMax Life).

CTC Blood Test Detects Early Stage Colorectal Cancer

Colorectal cancer is among the most preventable cancers when detected early. Yet, it is the second leading cancer killer in the USA. Traditional methods like colonoscopies and stool-based tests are invasive or inconvenient and compliance with colorectal cancer screening remains low, leading to most colorectal cancers being detected in late stages, when survival rates are poor. More...
13 Feb 2018
Image: A diagram of structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1 (Photo courtesy of the University of Ghent).

Key Mechanism of Autoimmune and Inflammatory Diseases Revealed

The prevalence of psoriasis, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis, has been rapidly expanding over the last few decades. A crucial aspect of the molecular basis of these autoimmune and inflammatory has been unraveled. More...
01 Feb 2018
Image: The diagnostic accuracy of the HostDx Sepsis assay compared to other methods (Photo courtesy of Inflammatix).

Immune Response Tests Enable Rapid Antibiotic Decisions

A novel test uses quantitative multiplex gene expression to analyze a patient's immune system, or the host response, rather than looking for the presence of a pathogen that indicates whether there is an infection in the blood. More...
31 Jan 2018
Image: T regulatory cells (also known as Tregs or Regulatory T cells) are essential cells that suppress immune responses of other cells, designed to limit excessive reactions and prevent autoimmunity. Tregs are characterized by the expression of CD4+, CD25+,and Foxp3+, while lacking CD127 (Photo courtesy of BioLegend).

Cellular Mechanism Identified for Severe Viral Hepatitis

It is known that activated immune cells of patients with viral hepatitis destroy hepatocyte, but its regulatory mechanism has not yet been described. Regulatory T cells (Tregs) inhibit activation of other immune cells and thus are important for homeostasis of the immune system. More...
29 Jan 2018
Image: Cytometry by time of flight (Cy-TOF) cell analysis apparatus (Photo courtesy of the University of Minnesota).

New Biomarkers Predict Outcome of Cancer Immunotherapy

Melanoma and lung cancer can be combatted effectively through immunotherapy, which makes targeted use of the immune system's normal function of regularly examining the body's tissue for pathogens and damages. More...
25 Jan 2018
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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