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BioResearch

Genetically Engineered Abolition of p62 in Fat Tissue Causes Obesity in Mice

A recent study linked the scaffold protein p62, an emerging key molecular link among the metabolic, immune, and proliferative processes of the cell, to the metabolic imbalance that leads to obesity. More...
17 Jan 2013

A T-Cell Cytokine Channels Tuberculosis into the Latent Form of the Disease

Molecular biologists studying tuberculosis have identified a T-cell surface protein that channels infection by Mycobacterium tuberculosis into the chronic, latent form of the disease rather than into the acute, active form. More...
17 Jan 2013
Image: These nanoparticles created by MIT engineers can act as synthetic biomarkers for disease. The particles (brown) are coated with peptides (blue) that are cleaved by enzymes (green) found at the disease site. The peptides then accumulate in the urine, where they can be detected using mass spectrometry (Photo courtesy of Justin H. Lo).

Nanoparticles Designed for Earlier Cancer Diagnosis

One way to earlier cancer detection is to search for specific proteins secreted by cancer cells that circulate in the bloodstream. More...
16 Jan 2013

Photoreceptor Cell Maintenance Depends on the TAM Ligands Protein S and Gas6

A paper described the role of the two TAM ligand proteins, Gas6 and Protein S, which are important players in immune regulation, cancer metastasis, and viral infection in maintaining the health of photoreceptor cells in the eye. More...
16 Jan 2013

Interaction of Cancer Stem Cells and the Tumor Microenvironment Regulates Growth and Progression of Ovarian Tumors

Recently published findings on the interaction of the growth factors Lin28, Oct4, and BMP4 unite two basic theories of how tumors develop and progress. More...
16 Jan 2013

Small Peptide Cures Alzheimer's Disease in Mouse Model by Blocking Cyclin-Dependent Kinase 5 Activity

A potential new treatment for AD is based on a peptide derived from the activator of the protein cyclin-dependent kinase 5, a critical neuronal kinase that is hyperactivated in the brains of AD patients. More...
15 Jan 2013

Metformin Lowers Glucose Levels by Blocking the Action of Liver Cell Glucagon

The diabetes drug metformin works by inhibiting formation of adenylate cyclase, which blocks liver cell glucagon-dependent glucose output, and not by reducing glucose synthesis by activating the enzyme AMPK as had been postulated previously. More...
15 Jan 2013
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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