Nanoparticle Suspension Captures and Purifies DNA from High-Value Samples

The PrepParticle suspension is pipetted directly into a crude sample, mixed with a binding buffer and centrifuged. Purified DNA is then released into that same tube, in a concentrated form, ready for genetic analysis. Easy-to-use protocols (manual and automated) are available for DNA isolation from blood, thin sections, and swabs.

A product of Argylla Technologies LLC (Tucson, AZ, USA), the nanoXtract kit with PrepParticles belongs to a suite of simple-to-use products being developed for the manipulation, capture, purification, and concentration of DNA, RNA, and proteins. The high-density nanoparticles form extremely stable suspensions with enormous surface areas in biologic fluids. Argylla exploited the unique physical properties of nanoparticles in suspension, and coated these particles with biomolecule-specific films to create a new class of tools for the biotechnology marketplace.

The extraction-capture-concentration process scales from liter size samples to samples as small as a 1/100th of a milliliter by a simple adjustment of the proportion of the Argylla particles used in the preparation. The PrepParticle can process samples yielding as little as 100 picograms of DNA.

The Argylla kit products can process micro-dissected clinical biopsies, crime scene wipes, clinical skin swabs, and clinical samples such as bacterial swabs. They are extremely simple to use, cost effective, and possess rapid binding kinetics associated with NanoChromatography processes. The nanoparticle matrix has enormous binding capacity, and the whole extraction process, from start to finish, is performed within one low cost standard microfuge tube.


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