We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
Sekisui Diagnostics

Download Mobile App




Daily Blood Testing May Help Guide Earlier Antibiotic Stopping in Sepsis

By LabMedica International staff writers
Posted on 23 Oct 2026
Sepsis is a life-threatening condition caused by the body’s overwhelming response to infection and accounts for thousands of deaths each year. More...
In intensive care, concern about stopping treatment too early often leads to prolonged antibiotic courses. However, unnecessary use can fuel antimicrobial resistance, increase side effects, and raise health care costs. To guide treatment duration more precisely, new findings suggest that daily blood biomarker testing may help identify when antibiotics can be stopped sooner.
 
Researchers at the University of Manchester and Northern Care Alliance NHS Foundation Trust led the ADAPT-Sepsis trial to evaluate whether daily blood tests could guide antibiotic-stopping decisions in critically ill patients with sepsis. The approach monitored blood biomarkers to generate automated treatment advice for clinicians. Specifically, the study compared recommendations based on procalcitonin (PCT) with those based on C-reactive protein (CRP), another commonly used marker.
 
The trial involved 2,760 patients treated in 41 intensive care units across the U.K. More than 17,000 blood samples and pieces of treatment advice were analyzed. The evaluation examined how doctors responded to automated recommendations generated from the daily biomarker tests.
 
PCT-based guidance generated “stop antibiotics” recommendations nearly two days earlier than CRP-based guidance. Doctors were more likely to follow advice generated from CRP testing, which more closely reflected existing prescribing habits and tended to recommend continuing standard care. The most common reason for not following stop recommendations was existing microbiology guidance recommending fixed treatment durations, followed by concerns about ongoing severe illness, persistent fever, and raised inflammation markers.
 
The findings were published in Anaesthesia on October 20, 2026. The research team stated that the new data add to evidence from the ADAPT-Sepsis research program and provide a final process evaluation on whether the approach could be adopted across the NHS.
 
“For decades, intensive care doctors have faced an impossible balancing act. Nobody wants to stop antibiotics too early and risk a patient's life, but continuing them unnecessarily also carries real dangers for individuals and society. What our study shows is that simple biomarker tests can provide an additional layer of reassurance when making these difficult decisions. The challenge now is helping health care teams feel confident acting on that information so patients receive exactly the treatment they need, for exactly as long as they need it,” said Paul Dark, vice dean for health and care partnerships at The University of Manchester and professor of critical care medicine at the Northern Care Alliance NHS Foundation Trust.
 
“Blood-test-guided antibiotic stewardship could become an important tool in the fight against antimicrobial resistance if implemented alongside existing clinical guidance and prescribing frameworks. These findings provide new insight into how hospitals could safely reduce antibiotic exposure in some of the sickest patients in the NHS while helping preserve the effectiveness of lifesaving drugs for future generations,” said Prof. Dark.

Related Links
University of Manchester
Northern Care Alliance NHS Foundation Trust

Platinum Member
Automated Coagulation Analyzer
Hemolumi H6
βeta-Hydroxybutyrate Reagent
β-Hydroxybutyrate LiquiColor®
New
Silver Member
Connectivity Solution
EKF Link
Gold Member
Fully-auto Specific Protein (Nephelometry) Analyzer
PA240
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Molecular Diagnostics

view channel
Image: The automated multiplex PCR assay runs on the BioFire Spotfire Vaginitis System, bringing molecular vaginitis testing to the point of care (Photo courtesy of bioMérieux)

Molecular Vaginitis Panel Gains FDA Clearance and CLIA Waiver for Point-of-Care Use

Vaginitis affects most women at least once in their lifetime and can cause painful, disruptive symptoms. Common causes include bacterial vaginosis, vulvovaginal candidiasis, and trichomoniasis, reflecting... Read more

Immunology

view channel
Image Credit: iStock

Antibody Profiling Predicts Inflammatory Bowel Disease Years Before Diagnosis

Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, involves abnormal immune responses that cause persistent inflammation and damage in the digestive system.... Read more

Pathology

view channel
Image: The CE-marked software IVD combines digital histopathology and clinicopathological data to generate a prognostic classification (Image Credit: Shutterstock)

Digital Pathology Test Stratifies Recurrence Risk in Early Breast Cancer

In hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer, accurate recurrence-risk assessment helps guide treatment decisions. However, individual risks... Read more

Technology

view channel
Image: Signals LabGistics uses AI to turn natural-language instructions and SOPs into coordinated scientific workflows, helping connect teams, systems, and processes. (Photo courtesy of Revvity)

New AI-Powered System Aims to Streamline Laboratory and Manufacturing Workflows

Scientific laboratories supporting drug development, biotechnology, and materials research increasingly rely on coordinated digital workflows to move data, samples, and activities across teams.... Read more

Industry

view channel
Image: The integration with FlexLab X brings the Panther System into fully tracked automation environments to increase capacity, traceability, and workflow efficiency (Photo courtesy of Hologic)

Hologic and Inpeco Partner to Advance Molecular Laboratory Automation in Europe

Hologic, Inc. (Marlborough, MA, USA) and Inpeco S.A. (Novazzano, Switzerland) have signed a co-marketing partnership in Europe for Inpeco’s recently launched FlexLab X automation solution and Hologic’s... Read more
Copyright © 2000-2026 Globetech Media. All rights reserved.