We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
Sekisui Diagnostics

Download Mobile App




Cell Implants Reduce Tumor Growth

By LabMedica International staff writers
Posted on 07 Dec 2009
Cancer researchers have reduced tumor mass and slowed tumor growth in a mouse model using a novel system of microcapsules that contain cells that continually produce anticancer proteins.

Investigators at the Technion-Israel Institute of Technology (Haifa, Israel) chose human mesenchymal stem cells (MSCs) as the basis for a unique drug delivery system. More...
MSCs are easy to obtain from bone marrow. These cells are hypoimmunogenic – they do not trigger an immune response – and can be genetically engineered to produce and secrete proteins of choice. To isolate and protect the MSCs they were sequestered inside polymeric microcapsules, which permitted the free exchange of oxygen and nutrients.

In the current study, the investigators employed MSCs that had been modified to produce hemopexin-like protein (PEX), an inhibitor of angiogenesis. Microcapsules containing the modified MSCs were injected adjacent to glioblastoma tumors in nude mice. Results published in the September 2, 2009 online edition of the FASEB journal revealed that this treatment caused a significant reduction in tumor volume (87%) and weight (83%).

Previous attempts to use encapsulated cells were not successful due to the immune reaction that they induced. Relating to the current study, senior author Dr. Marcelle Machluf, professor of biotechnology at the Technion, said, "Our method should overcome this problem. We are using MSCs, which are known to be hypoimmunogenic (that is, they reduce the body's immune reaction), and which are taken from human bone marrow. We then implant them inside an encapsulated system that protects them from the environment into which they are placed.”

Related Links:

Technion-Israel Institute of Technology




Platinum Member
Automated Coagulation Analyzer
Hemolumi H6
Gold Member
Fully-auto Specific Protein (Nephelometry) Analyzer
PA240
New
Gold Member
Serum Indices Control
Acusera Serum Indices Control
New
Fully Automated Urinalysis System
DxU 1800 Fully Automated Urinalysis System
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Clinical Chemistry

view channel
Image Credit: 123RF

Screening After Pneumococcal Disease May Reveal Undiagnosed Blood Cancer or Immune Disorders

Severe pneumococcal disease requiring hospitalization often presents as pneumonia, particularly in older adults and people with cancer or compromised immune function. Because M protein testing and antibody... Read more

Microbiology

view channel
Image Credit: 123RF

FDA-Cleared Multiplex PCR Test Detects 13 Respiratory Pathogens in a Single Sample

Respiratory tract infections can be difficult to distinguish at presentation because many cause overlapping, nonspecific symptoms and are initially grouped as influenza-like illnesses. Causes span a range... Read more

Technology

view channel
Image: The laser-based photoacoustic spectroscopy setup consists of a Mid-IR laser equipped with three QCL modules covering wavelengths from 5.6 μm to 12.9 μm, two silver coated mirrors (SCM), a dichroic mirror (DM) with a transmittance of 90%, a thermal power sensor head (PM) to monitor the output laser power, a mechanical chopper (MC) for frequency modulation and a CEPAS-detector with a self-designed swab holder (SH). (Credit: Graunke, T., Scholz, T., Pieniak, M. et al. Scientific Reports (2026). https://doi.org/10.1038/s41598-026-68298-9)

Laser-Based Swab Analysis Shows Promise for Detecting Disease-Linked Odor Patterns

Disease-related changes in volatile organic compounds can alter body odor, producing measurable patterns in exhaled breath and bodily fluids. Current analytical methods can be complex, time-consuming,... Read more

Industry

view channel
Image

Collaboration Combines AI Cognitive Assessment and RNA Blood Testing for Earlier Alzheimer’s Detection

Alzheimer’s disease is often identified only after substantial neurodegeneration, partly because current diagnostic pathways are fragmented and difficult to scale. As treatment shifts toward earlier intervention,... Read more
Copyright © 2000-2026 Globetech Media. All rights reserved.