Kinase Assay Optimized

(Waltham, MA, USA), announced that it has expanded its successful portfolio of HTS Lance assays with the release of Lance Ultra. The improved time-resolved fluorescence resonance energy transfer (TR-FRET) technology accelerates speed and precision of kinase assay development and optimization.

"Protein kinases regulate several important functions within cells, such as growth, proliferation, and cell adhesion, making it one of the most important areas of study in today's pharmaceutical and biotech laboratories,” said Dr. Richard Eglen, vice president and general manager of the Discovery and Research Reagents business of PerkinElmer Life and Analytical Sciences. "The addition of Lance Ultra to PerkinElmer's broad offering of TR-FRET assay tools creates one of the industry's largest portfolios targeting high value functional biochemical and cell based assays.”

Lance Ultra utilizes ULight, an innovative, low-molecular weight red-shifted fluorescent dye that greatly enhances the performance of TR-FRET assays by increasing the range of targets that can be identified. Dr. Eglen said, "Dysregulation of kinase activity plays causal roles in many human diseases, making kinases one of today's most important drug discovery target classes.”

Lance Ultra reagents are specifically engineered for the precise development and optimization of kinase and enzyme assays, as well as for monitoring protein-protein interactions. Ultra high throughput screening applications such as Lance Ultra are easily adapted to any TR-FRET capable plate reader such as the PerkinElmer ViewLux uHTS imaging system or EnVision multimode reader, enabling greatly improved precision and remarkable throughput.

In addition to its broad range of traditional Lance technologies, PerkinElmer has significantly enhanced its custom reagents service, offering expert labeling of a wide variety of peptides, proteins and antibodies with PerkinElmer's proprietary europium and lanthanide chelate donor dyes, and ULight or allophycocyanin (APC) acceptor dyes.


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