New Renal Disease Genes Identified

The principles were applied to a set of genes linked to the unique functional unit of the glomerular slit diaphragm, and an evolutionary promoter model was generated.

Genome-wide scans using this promoter model predicted an unrecognized slit diaphragm molecule that was successfully identified. The authors show how a straightforward approach to comparative promoter analysis can identify regulatory pathways in tissue homeostasis and disease processes.

The analysis was a joint effort of the Medizinische Poliklinik, University of Munich (Munich, Germany), the University of Bristol's children's renal unit (Bristol, UK), the German Cancer Research Center (Heidelberg, Germany), and Sanova-Aventis (Frankfurt, Germany), led by Genomax Software GmbH (Munich, Germany).

Genomax analyzes eukaryotic gene regulation. The company's strategy and product integration allow efficient handling of low-level analysis from raw expression data, pathway/network analysis, and biologic classification and identification of the molecular basis for co-regulation on the gene-promoter level.



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