Cytoplasmic p53 Triggers Mitochondrial Apoptosis Pathway

The Bax protein is a pro-apoptotic member of the Bcl-2 family of proteins that regulate the mitochondrial apoptosis pathway. Bax plays a pivotal role in the regulation of release of cell death-activating factors from mitochondria.

"We have discovered a new pathway for p53 to trigger the process that leads to cell death,” said senior author Dr. Douglas L. Green, a researcher at the La Jolla Institute for Allergy and Immunology. "This is another piece of the puzzle of how tumor cells are regulated and it could lead to better treatment for cancers and other diseases.”



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La Jolla Institute for Allergy and Immunology