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Pathology

Image: A new technique distinguishes cell types in blood by looking at signature degrees of methylation in DNA. Yellow represents no methylation, blue full methylation (Photo courtesy of Brown University).

Quantization of Leukocyte Subsets with DNA Methylation Microarrays

A novel microarray-based technique uses DNA methylation to simultaneously quantify multiple leukocyte subsets, enabling the investigation of immune modulations in both fresh blood samples and archived samples that previously could not be used for such analysis.  More...
20 Mar 2014

Bone Metabolism Biomarkers Predict Prostate Cancer Survival

Levels of biomarkers linked to bone metabolism are indicative of survival in patients with castration-resistant prostate cancer, and identify a small group of patients who can benefit from treatment with the investigational drug atrasentan.  More...
19 Mar 2014

Urinary RNA Assay May Replace Needle Biopsy for Detection of Kidney Transplant Rejection

Determination of mRNA signatures in urine samples may replace needle biopsy for diagnosing kidney dysfunction following transplant surgery.  More...
17 Mar 2014
Caption: Bone marrow stained with Dako's Jenner-Wright Giemsa: nuclei – blue; eosinophils – bright pink; lymphocytes – shades of pink, gray, or blue depending on cell type and development (Photo courtesy of Dako).

Specialized Stain Enables Exceptional Bone Marrow Diagnostic Pathology

A new tissue stain has been specially developed to provide superior clarity of differentiation and detail in bone marrow tissue samples for disease diagnosis.    More...
13 Mar 2014
Image: The ALK gene is located on the short (p) arm of chromosome two at position 23 (Photo courtesy of the [US] National Institutes of Health).

New PCR Assay Detects Gene Rearrangements in Preserved Samples from Lung Cancer Patients

A sensitive and robust routine diagnostic test for the detection of rearrangements and transcriptional upregulation of the ALK gene was described in a recent publication.  More...
13 Mar 2014

Combined Screening Suggested to Better Detect ALK Rearrangements in Samples from Non-Small-Cell Lung Cancer Patients

Anaplastic lymphoma kinase rearrangements occur in 1% to 7% of non-small-cell lung cancers, but nearly 25% of samples from NSCLC patients with ALK rearrangements were not identified when analyzed by either fluorescent in situ hybridization or immunohistochemistry.  More...
12 Mar 2014

Rise in Blood Levels of Heart Muscle Protein an Early Diagnostic Marker for Cardiac Injury

The heart muscle protein cMyBP-C is rapidly released into the bloodstream after cardiac damage and may be a sensitive biomarker for diagnosing the onset of myocardial infarction.  More...
10 Mar 2014
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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