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Pathology

Image: Histopathology of esophageal carcinoma showing infiltrating nests of neoplastic cells (Photo courtesy of Dr. Elliot Weisenberg, MD).

Multianalyte Test Predicts Drug Resistance in Esophageal Cancer

A multianalyte algorithmic immunohistochemistry assay accurately identifies patients with locoregional esophageal adenocarcinoma who exhibit extreme resistance to neoadjuvant chemoradiotherapy.   More...
16 Mar 2015
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Breast Cancer Test Links Immune Hotspots to Better Survival

A new test has been developed that can predict the survival chances of women with breast cancer by analyzing images of hotspots where there has been an intense immune reaction to a tumor.   More...
15 Mar 2015
Image: Immunohistochemistry of formalin fixed paraffin-embedded sections from breast carcinoma stained with Estrogen Receptor alpha antibody (Photo courtesy of Abcam).

Blood-Based Diagnostic Determines Hormonal Status of Metastatic Breast Cancer Patients

Estrogen receptor and progesterone receptor status is prognostic and predictive in breast cancer and because metastatic breast tumor biopsies are not routinely feasible, circulating tumor cells offer an alternative source of determining ER/PR tumor status.  More...
11 Mar 2015
Image: Erlotinib bound to EGRF at 0.26 nm resolution; surface color indicates hydrophobicity (Photo courtesy of Wikimedia Commons).

Analysis of Circulating Free DNA May Replace Tumor Biopsy for Detection of Non-Small-Cell Lung Cancer

A recent paper showed that analysis of circulating free DNA in blood samples could replace biopsy as a means for detecting patients with advanced non-small-cell lung cancer that was distinguished by oncogenic epidermal growth factor receptor mutations.  More...
10 Mar 2015
Image: Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the substantia nigra in Parkinson\'s disease (Photo courtesy of the Michael J. Fox Foundation).

Skin Test Helps Diagnose Alzheimer's and Parkinson's Diseases

Skin biopsies can be used to detect elevated levels of abnormal proteins found in Alzheimer's and Parkinson's Diseases and may shed new light on both.  More...
08 Mar 2015

Aggressive Bladder Cancers May Be Identified by Measuring Two Urinary Proteins

British cancer researchers have found that measuring the urinary proteins epidermal growth factor receptor and epithelial cell adhesion molecule may represent a simple and useful approach for diagnosing and treating patients with the most aggressive bladder cancers.  More...
08 Mar 2015
Image: Various types of leukocytes within a blood sample used for a differential white blood cell count to determine the relative percentages (Photo courtesy of Dr. Kristine Krafts MD).

Blood Tests Help Identify Children Who Need Appendectomy

Appendicitis is the most common abdominal surgical emergency in the pediatric population, yet the diagnosis remains challenging in many cases and the use of laboratory data as a diagnostic adjunct has similarly been associated with relatively low sensitivity, and children with pathology-proven appendicitis can often present with a normal leukocyte count  More...
04 Mar 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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