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Pathology

Image: The Invitrogen Qubit Fluorometer for routine DNA, RNA, and protein quantitation (Photo courtesy of Life Technologies).

Endoscopic Samples Show Precancerous Genomic Changes in Barrett's Esophagus

Next-generation sequencing has been used to detect genomic mutations in precancerous esophageal tissue, which may improve cancer surveillance and early detection in patients with Barrett's esophagus.  More...
22 Jun 2015
Image: Micrograph of plasma cell with distinct clear perinuclear region of the cytoplasm containing a large number of Golgi bodies (Photo courtesy of Wikimedia Commons).

Circulating Biomarker for Autoimmune Disease Activity Identified

A circulating biomarker has been identified that shows potential for monitoring autoimmune diseases such as multiple sclerosis and lupus erythematosus.  More...
22 Jun 2015
Image: Highly magnified view of brain tumor (glioma) cells (Photo courtesy of the University of California, San Francisco).

Panel of Genetic Biomarkers Separates Brain Tumors into Five Distinct Classes

A panel of three genetic biomarkers has been identified that can differentiate brain tumors into five principal groups.  More...
21 Jun 2015
Image: Histopathology of a biopsy smear from a patient with squamous cell carcinoma in the anal canal showing proliferation of atypical cells that infiltrate the stromal (Photo courtesy of Muñiz Hospital).

Biomarker Analysis Reveals Treatment Targets in Anal Cancer

Squamous cell anal carcinoma is a rare, human papillomavirus-associated malignancy accounting for 2% of digestive system cancers and usually these malignancies are detected early and successfully managed with chemoradiation.  More...
16 Jun 2015
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Computer-Aided Microscopy Facilitates Autoimmune Disease Diagnostics

A new software and immunofluorescence microscope system that supports automated imaging and interpretation for clinical diagnostics now provides specialized software for autoimmune disease identification, including analysis of anti-nuclear antibodies and anti-neutrophil cytoplasm antibodies.   More...
15 Jun 2015
Image: Immunohistochemical staining of human testis with antibody to AKAP4 shows location of the protein in spermatids (Photo courtesy of Novus Biologicals).

AKAP4 Identified as Accurate Biomarker for the Detection of Early Stage Lung Cancer

An initial survey identified the protein AKAP4 as a potential biomarker that could effectively distinguish between patients with and without non-small-cell lung cancer.  More...
14 Jun 2015
Image: The LightCycler 480 II rapid high-throughput, plate-based real-time polymerase chain reaction (PCR) amplification and detection instrument (Photo courtesy of Roche).

Ovarian Cancer-Specific Markers Leads to Early Diagnosis

While DNA carries all the instructions necessary for life, its actual sequence contains much more than just the genes that code for proteins, while in contrast messenger ribonucleic acids are complementary copies of just the genes.  More...
08 Jun 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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