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Pathology

Image: Immuno-wall chips with the photo reactive polymer in the center of the 40 microchannels are made with a biotinylated anti-R132H-IDH1 antibody (HMab-2), an anti-wild-type IDH1 antibody (RcMab-1), and fluorescent antibodies. It shows sensitive and specific fluorescence from mutant IDH1 (Photo courtesy of Nagoya University).

Novel Device Enables Rapid Identification of Brain Cancer Type

A device has been developed for quick, accurate identification of a mutation strongly associated with a cancer that affects the central nervous system, potentially enabling accurate removal of the entire tumor during an operation. More...
20 Oct 2016
Image: The Guardant360 kit for biopsy-free tissue sequencing for cancer (Photo courtesy of Guardant Health).

Liquid Biopsy Tests Identified Cell-Free Tumor DNA Mutations

The feasibility of using cell-free circulating tumor DNA (ctDNA) next-generation sequencing (NGS) from liquid biopsies as a complement or alternative to tissue NGS has been evaluated. More...
20 Oct 2016
Image: A histopathology of non-alcoholic steatohepatitis (NASH) in a liver biopsy (Photo courtesy of SPL).

Simple Blood Test Vastly Improves Severe Liver Disease Detection

A new non-invasive method of predicting the risk of developing a severe form of liver disease could ensure patients receive early and potentially life-saving medical intervention before irreversible damage is done. More...
19 Oct 2016
Image: The Quantum Blue rapid test allow for the immediate measurement of fecal calprotectin (Photo courtesy of Bühlmann Laboratories).

Unnecessary Endoscopies Could Be Avoided with Fecal Blood Test

The majority of primary care patients referred for bowel endoscopy do not have significant colorectal disease (SCD), and are unnecessarily exposed to a small but realistic risk of severe endoscopy-associated complications. More...
14 Oct 2016
Image: An experiment examining retina tissue for mHtt deposition in GFAP-ir astrocytes in R6/2 mouse model of Huntington’s Disease. Green: glial fibrillary acidic protein (GFAP); Red: mutant huntingtin protein (mHtt). (A) A low magnification picture illustrates GFAP-ir astrocytes and mHtt deposits from the retinal wholemount of 12-week-old R6/2 (Huntington’s disease model) mouse. Scale bar = 50 µm. (B) A detailed confocal analysis of GFAP positivity, mHtt immunoreactivity, and DAPI counterstain (blue) revealed no colocalization of GFAP and mHtt. Scale bar = 20 µm (Image courtesy of PLoS One).

Changes in Eye Tissue May Enable Early Detection of Brain Diseases

Research with mouse models has shown that at least some diseases of the central nervous system (CNS) manifest as pathological changes in the retina of the eye and that these changes may be detected earlier than brain changes. The findings suggest that eye examination could be used for minimally invasive screening for these diseases. More...
11 Oct 2016
Image: A histology image analysis and validation of the automatic test (Photo courtesy of the Institute of Cancer Research).

Automated Test Strongly Predicts Ovarian Cancer Survival

The tumor microenvironment is pivotal in influencing cancer progression and metastasis and different cells co-exist with high spatial diversity within a patient, yet their combinatorial effects are poorly understood. More...
06 Oct 2016
Image: The Prolaris assay measures how fast the cells in the prostate tumor are dividing (Photo courtesy of Myriad Genetics).

Genomic Fingerprinting Helps Predict Prostate Tumor Aggressiveness

Next-generation sequencing is revealing genomic heterogeneity in localized prostate cancer (CaP), but incomplete sampling of CaP multiclonality has limited the implications for molecular subtyping, stratification, and systemic treatment. More...
06 Oct 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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