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Pathology

Image: The Guardant360 kit for biopsy-free tissue sequencing for cancer (Photo courtesy of Guardant Health).

Comprehensive Liquid Biopsy Guides Metastatic Cancer Treatment

Liquid biopsies offer a promising approach for identifying druggable genomic alterations, which is the ability of a portion of a genome to be targeted by a drug, especially by a small molecule drug, without the need for costly and invasive tissue biopsies. More...
21 Jun 2016
Image: Researchers have developed a new blood test that is able to detect the early stages of Alzheimer\'s Disease (Photo courtesy of Rowan University).

Autoantibody Panel Accurately Diagnoses Early-Stage Alzheimer's Disease

A blood test based on a panel of 50 autoimmune antibodies was shown to detect individuals with mild cognitive impairment (MCI) stage Alzheimer’s disease (AD) with an overall accuracy, sensitivity, and specificity rate of 100%. More...
20 Jun 2016
Image: Assay principles: Unpurified PCR product is added to a micro well containing probe-conjugated microbeads. A wild-type target hybridizes efficiently to both probes, inducing bead aggregation. Hybridization of a mutant target to the discriminating probe is unfavorable; therefore, the beads remain dispersed. An image of each micro well is obtained and processed to generate a saturation value corresponding to the extent of aggregation (Photo courtesy of The Journal of Molecular Diagnostics).

Rapid Technique Described for Detection of KRAS Mutations in Pathology Specimens

A recent paper described a rapid and inexpensive method for detecting KRAS mutations in clinical biopsy specimens of lung and colorectal cancers. More...
20 Jun 2016
Image: The AbsoluteIDQ p180 Kit for Metabolic Phenotyping (Photo courtesy of Biocrates Life Sciences).

Blood Metabolites Tests Helps Tailor Cancer Treatment

As a minimally invasive assessment, plasma metabolomic analysis has the potential to complement direct tumoral measurements and, particularly where cancer biopsies are unavailable, and can report on the integrated output of multiple systems including sites of disease. More...
15 Jun 2016
Image: The cobas epidermal growth factor receptor EGFR Mutation Test v2 (Photo courtesy of Roche Molecular Systems).

Blood Test Detects Gene Mutation Associated with Lung Cancer

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and NSCLC tumors may shed tumor DNA into a patient's blood, making it possible to detect specific mutations in blood samples. More...
14 Jun 2016
Image: A diagram of Merkel cell polyomavirus preferentially infecting dermal fibroblasts in human skin (Photo courtesy of Jianxin You, PhD).

Merkel Cell Polyomavirus Infection Can Cause Lethal Carcinoma

A benign virus normally found in the skin can lead to a type of rare, lethal skin cancer; specifically, infection by the Merkel cell polyomavirus can lead to Merkel cell carcinoma in immune-compromised individuals. More...
14 Jun 2016
Image: The ability of cancer cells to move and spread depends on actin-rich core structures such as the podosomes (yellow) shown here in melanoma cells. Cell nuclei (blue), actin (red), and an actin regulator (green) are also shown (Photo courtesy of Julio C. Valencia and Daniel Mietchken, via Wikimedia).

Early Detection Among Benefits of Skin Cancer Screening at Primary Care Visits

According to new research, skin cancer screenings performed by primary care physicians (PCPs) during routine office visits improves detection of potentially deadly melanomas and find them in earlier stages. More...
13 Jun 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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