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Pathology

Image: Dr. Xiang Zhang implementing the bone-in-culture array, a platform to model early-stage bone metastases and discover the fate of cancer cells (Photo courtesy of Baylor College of Medicine).

New Technique Tests Therapies for Cancer Metastasis

A new laboratory technique has been developed that can rapidly test the effectiveness of treatments for life-threatening, breast cancer metastases in bone. Until now, there has not been an effective laboratory platform to study metastatic tumors in their new microenvironment. More...
10 May 2017
Image: A histopathology of breast cancer:  intraductal carcinoma, noncomedo type, distended duct with intact basement membrane, micropapillary, and early cribriform growth pattern membrane and central tumor necrosis (Photo courtesy of Dr. Peter Abdelmessieh).

Multigene Test Extends Life Expectancy for Cancer Patients

Testing for variants in seven cancer-associated genes, versus the usual process of testing in just two genes, followed by risk-reduction management could cost-effectively improve life expectancy for women at risk of hereditary breast cancer. More...
04 May 2017
Image: An immunohistochemistry of fine needle aspirates in acinic cell carcinoma (AciCC) for SRY-related HMG-box 10 (SOX10) and 2-deoxyglucose-6-phosphate phosphatase (DOG1) (Photo courtesy of Emory University School of Medicine).

Ancillary Tests Developed for Salivary Gland Pathology

Salivary gland tumors represent a diverse set of tumors with a broad range of biologic behaviors, ranging from completely benign tumors to low-grade malignancies to high-grade malignancies. More...
03 May 2017
Image: The LSM 700 laser scanning microscope (Photo courtesy of Zeiss).

Biomarker Identified for Aggressive Early Stage Cancer

Breast cancer begins as anomalous cells that divide out of control, usually in the milk ducts and in almost all cases, a patient does not succumb to the initial cancer but to the secondary tumors after the cancer has spread. More...
27 Apr 2017
Image: Fluorescence micrograph of captured plasma cells from a clinical sample. Red fluorescence denotes CD138, while green denotes κ light chain antibody (Photo courtesy of Massachusetts Institute of Technology).

Novel Technique Captures Plasma Cells from Myeloma Patients

Multiple myeloma is a cancer of the plasma cells, which are white blood cells produced in bone marrow that churn out antibodies to help fight infection. When plasma cells become cancerous, they produce abnormal proteins, and the cells can build up in bone marrow, ultimately seeping into the bloodstream. More...
27 Apr 2017
Image: A diagram of the method developed to detect and map DNA methylation, which can be a sign of cancer, by threading the DNA through a tiny hole in a thin sheet of conductive material with a current running through it (Photo courtesy of Aditya Sarathy, University of Illinois).

Detecting Cancer as DNA Changes Could Enhance Diagnosis

DNA methylation is an epigenetic modification involving the addition of a methyl group to DNA, which is heavily involved in gene expression and regulation, thereby critical to the progression of diseases such as cancer. More...
26 Apr 2017
Image: A photomicrograph of abnormal cervical cells staining positive for CINtec PLUS test (Photo courtesy of Ventana Medical Systems).

Cytology Test for Pre-Cancer Diagnosis Receives FDA Approval

A cytology test, which is the only clinically validated cyclin-dependent kinase inhibitor 2A (p16) biomarker test that, when used in conjunction with hematoxylin & eosin (H&E) staining, helps pathologists determine which women should receive treatment for cervical pre-cancer. More...
25 Apr 2017
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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