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Immunology

Image: The Simoa HD-1 ultrasensitive immunoassay platform (Photo courtesy of Quanterix).

Blood Test Differentiates Parkinson's from Similar Diseases

In early stages of disease, it can be difficult to differentiate between Parkinson's disease and atypical parkinsonism disorders (APDs) like multiple system atrophy, progressive supranuclear palsy and corticobasal degeneration, because symptoms can overlap. More...
22 Feb 2017
Image: Escherichia coli bacteria (red), which are abundant in the immunoglobulin-A-coated microbiota of patients with a Crohn\'s disease-associated condition called spondyloarthritis, promote systemic inflammation. The blue circular structures depict the nuclei of cells called epithelial cells (Photo courtesy of Dr. Kenneth Simpson, Cornell University).

Bacteria Links Crohn's Disease to Spondyloarthritis

Peripheral spondyloarthritis (SpA) is a common extraintestinal manifestation in patients with active inflammatory bowel disease (IBD) characterized by inflammatory enthesitis, dactylitis, or synovitis of nonaxial joints. More...
22 Feb 2017
Image: The technology consists of a chip with peptide arrays for binding antibodies in blood samples from patients and healthy individual, and is enabling researchers to discover, define, and detect immunosignatures for various diseases (Photo courtesy of ASU Biodesign Institute).

Immunosignaturing Platform Provides Pre-Symptom Diagnostics

Researchers have developed an immunosignature profiling technology aimed to provide people with a means of monitoring their health status and a means for early detection of disease by rapidly testing for many diseases at once from a single drop of blood. In addition, the versatile technology could be used to secure a nation’s blood supply or give early warning of a disease epidemic. More...
21 Feb 2017
Image: The Dade Behring BN II automated nephelometer system (Photo courtesy of Siemens Healthcare).

Low Levels of Klothos Linked to Kidney Function Decline

The kidney has the highest levels of klotho expression and is likely the major source of soluble klotho and not surprisingly, therefore, levels of klotho tend to be low in patients with kidney disease. More...
15 Feb 2017
Image: A new technique for identifying tumor-derived extracellular vesicles (EVs) relies on differently shaped nanoparticle probes that refract light at different wavelengths, one spherical (green) and one rod-shaped (red). One probe identifies the surface protein ephA2 linked with pancreatic cancer; the other probe identifies a common EV surface protein. Only pancreatic cancer-derived EVs express both proteins and thus bind both nanoparticles to emit a brilliant yellow signal that allows these disease-linked EV’s to be easily detected for diagnostic purposes. This method can also be used to monitor effectiveness of anti-cancer treatment by measuring abundance of tumor-derived EV’s over the course of therapy (Photo courtesy of Arizona State University / Jason Drees).

Marker Detection Leads to Earlier Pancreatic Cancer Testing

With nanoplasmonic technology that enabled quantification of tumor-derived extracellular vesicles (EVs) in patient blood plasma microsamples, researchers have developed a noninvasive, inexpensive, rapid test for early diagnosis of pancreatic cancer (PC) as well as for monitoring of treatment-response and cancer burden in patients with PC. More...
15 Feb 2017
Image: The cobas e 601 heterogeneous immunoassay analyzer (Photo courtesy of Roche).

Biomarker Predicts Outcome in Persistently Unconscious Patients

Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. More...
09 Feb 2017
Image: The Spectramax M3 plate reader (Photo courtesy of Molecular Devices).

Seropositivity Thresholds Defined for Use in Trachoma Elimination Studies

Trachoma is caused by ocular infection with the bacterium Chlamydia trachomatis and it is the leading infectious cause of blindness worldwide. It is estimated that over 200 million people in 42 countries are at risk from trachoma blindness. More...
01 Feb 2017
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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