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BioResearch

Image: Forebrain of a mouse genetically engineered to express the mutated gene that causes Timothy Syndrome (TS) shows fewer neurons contributing to a brain structure responsible for long-distance communications between the left and right hemispheres, called the corpus callosum, compared to the same structure in a control animal (Ctrl). Human iPSCs from TS patients showed a similar reduction (Photo courtesy of Ricardo Dolmetsch, PhD, Stanford University).

Neurons Grown from Skin Cells May Hold Clues to Autism

Using a groundbreaking “disease-in a-dish” technique, researchers have grown patients’ skin cells into neurons to discover what goes wrong in the brain in Timothy syndrome. More...
28 Dec 2011

Novel Enzyme Binding Mechanism Dooms LDL-Receptors

Cardiovascular disease researchers have described the mode of action of an enzyme that regulates levels of LDL-cholesterol by marking LDL-receptors for degradation by the cell’s protein recycling mechanism. More...
27 Dec 2011

Alzheimer’s Antibodies Created to Target Harmful Proteins for Treatment Possibilities

A simple process was used to make antibodies that neutralize the harmful protein particles that lead to Alzheimer’s disease. More...
27 Dec 2011

Despite Promising Results in Mice MS Drug Laquinimod Disappoints in Human Trials

Experiments in an animal model of MS yielded evidence indicating that the experimental drug laquinimod stimulated immune cells within the central nervous system to produce the  brain-derived neurotrophic factor, contributing to the survival of neurons. More...
26 Dec 2011

Statins Help Lower Risk of Atherosclerosis by Reducing the Size of Arterial Plaques

Statins, a class of drugs that help reduce risk of atherosclerosis by lowering levels of low-density lipoproteins, also decrease the size of arterial plaques by stimulating macrophage emigration. More...
26 Dec 2011

Strategy Devised to Separate and Identify Thousands of Protein Molecules

A team led by a Northwestern University chemical biologist has developed a new “top-down” strategy that can rapidly separate and identify thousands of protein molecules. More...
26 Dec 2011

Bile Acid-Related Drug Protects Against Atherosclerosis

A modified bile acid is a candidate drug that has shown considerable promise by reducing the number of macrophages associated with atherosclerotic plaques and preventing atherosclerosis in a mouse model. More...
22 Dec 2011
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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