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Image: Complement C7 was identified through multi-omics analysis, validated across MASLD cohorts, localized to hepatic stellate cell-rich fibrotic regions, and linked to extracellular matrix remodeling. (Image Credit: Dr. Takefumi Kimura from Shinshu University, Japan)

Multi-Omics Study Identifies Blood Marker for MASLD Progression

Researchers identify a blood-based marker that stratifies liver fibrosis and predicts future liver-related events in MASLD. Read more
12 Oct 2026 | Clinical Chem.
Image: WashU Medicine researchers have found that a ratio between two immune cell types can reveal whether someone stays healthy or may face a higher risk of future disease. They found that having more granzyme K-producing white blood cells tipped the scale toward healthy aging, while having more granzyme B-producing cells was associated with chronic disease and even death. (Photo courtesy of Sara Moser/WashU Medicine)

Blood-Based Immune Aging Map Could Help Spot Disease Risk Earlier

Researchers identify an immune cell marker that gauges immune aging and predicts 10-year mortality and disease risk. Read more
12 Oct 2026 | Immunology
Image: Laboratory specialists and clinicians from 48 countries participated in this survey. Countries are indicated in red. (Omosule, Catherine L., Lang, Tim, Geaghan, Sharon M., et al. Mapping pediatric cardiac troponin testing worldwide: results from the IFCC survey on emerging applications, standardization needs and access. Chemistry and Laboratory Medicine (CCLM), 2026. https://doi.org/10.1515/cclm-2026-0711)

Global Survey Finds Pediatric Troponin Testing Lacks Consistent Reference Intervals

New data reveal lack of pediatric troponin reference intervals, hindering interpretation and prompting development of standards. Read more
12 Oct 2026 | Clinical Chem.
Image: The AidaBREAST assay integrates multimodal data to provide patient-specific 10-year recurrence risk and individualized predictions of radiation therapy benefit (photo courtesy of PreludeDx)

Validated Test Predicts Recurrence Risk and Radiation Benefit in Early-Stage Breast Cancer

A new multi-omic AI test predicts 10-year locoregional recurrence and radiation benefit in early-stage breast cancer. Read more
12 Oct 2026 | Molecular Diagnostics
Image: Natera\'s MCED assay analyzes cell-free DNA in blood to screen for multiple cancers (Image Credit: Adobe Stock)

Multi-Cancer Screening Blood Test Gains FDA Breakthrough Designation

Natera’s  multi-cancer early detection (MCED) assay has received Breakthrough Device designation from the FDA. Read more
12 Oct 2026 | Industry
Image: The European CE marking represents the third CDx approval for ETCAMAH and the 31st CDx approval for Guardant Health (Photo courtesy of Guardant Health)

European Approval Expands Liquid Biopsy Use in Advanced Breast Cancer Testing

Guardant Health’s Guardant360 CDx has received CE marking as a companion diagnostic for AstraZeneca’s ETCAMAH. Read more
12 Oct 2026 | Industry
Image Credit: Adobe Stock

Blood-Based Immune Signal Could Reveal Lung Cancer Risk Before Tumors Develop

New findings demonstrate a blood-based immune signal that may indicate lung cancer risk years before a tumor develops. Read more
09 Oct 2026 | Immunology
Image: Overview of the multiple-instance learning (MIL) workflow, in which each TMA core image is represented as a bag of patches that are encoded and aggregated to generate a slide-level prediction. (Giner F, Pastor-Naranjo Á, Meseguer P, et al. International Journal of Molecular Sciences, 2026. DOI: 10.3390/ijms27156864)

AI Histopathology Tool Distinguishes Ewing Sarcoma for Diagnosis

An AI approach analyzes digitized histology to distinguish Ewing sarcoma from similar tumors with 97% sensitivity, guiding workup. Read more
09 Oct 2026 | Pathology
Image: Neonatal sepsis research team with Hon Stephen Dawson WA Minister for Science and Innovation; Medical Research. (Photo courtesy of Murdoch University)

Prototype Point-of-Care Test Aims to Improve Neonatal Sepsis Diagnosis

A new point-of-care test using four biomarkers targets over 95% accuracy for neonatal sepsis at first suspicion vs 60%. Read more
09 Oct 2026 | Immunology
Photo courtesy of National Human Genome Research Institute

Genomic Screening Expands Detection of Treatable Conditions in Newborns

New data show genomic newborn screening augments standard tests by detecting missed treatable conditions earlier. Read more
09 Oct 2026 | Molecular Diagnostics
Image: NMPA approvals for Quanterix HD-X and SR-X instruments and four neurology biomarker assays expand access to ultrasensitive blood-based testing in China (Photo courtesy of Quanterix Corporation)

Regulatory Milestone Expands Access to Blood-Based Neurology Biomarker Testing in China

Quanterix and Innovita announced Chinese regulatory approvals for SIMOA technology and neurology biomarker testing. Read more
09 Oct 2026 | Industry
Image: Dr. Olivia Belbin, head of the Molecular Neurodegeneration Group at IR Sant Pau and study corresponding author, with Alba Cervantes (right), first author and IR Sant Pau researcher (Photo courtesy of IR Sant Pau)

Blood Biomarker Detects Alzheimer’s Changes Decades Before Symptoms in Down Syndrome

A blood-based marker detects Alzheimer’s-related brain changes decades before symptoms appear in people with Down syndrome. Read more
08 Oct 2026 | Clinical Chem.
Image Credit: Adobe Stock

Age-Based Genetic Testing May Miss Most Inherited Cancer Risk Variants

New findings show age-based germline testing misses 72% of pathogenic variants in solid tumors Read more
08 Oct 2026 | Molecular Diagnostics

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Clinical Chemistry

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Elevated Lipoprotein(a) Linked to Long-Term Progression of Carotid Atheroscleros...
Lollipop-Inspired Device Measures Acetaminophen Levels in Saliva
New Insights Into Fetal DNA Could Improve Non-Invasive Prenatal Testing
Image Credit: Adobe Stock

Study Questions Broad Fasting Requirements Before Routine Blood Tests

Routine blood testing is central to diagnosis, monitoring, and disease risk assessment. Many patients are still asked to fast for 8–12 hours before phlebotomy, even though the requirement was originally... Read more

Molecular Diagnostics

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Tumor-Informed ctDNA Test Shows Utility Across Gastrointestinal and Gynecologic ...
Pooled Sputum Testing Offers Lower-Cost Molecular Diagnosis for Tuberculosis
Tumor Markers Help Predict Response to Less Intensive HER2+ Chemotherapy
Image: The LymphoTrack Flex suite is an integrated next-generation sequencing solution for identifying and tracking immunoglobulin and T-cell receptor gene rearrangements (Photo courtesy of Invivoscribe)

New NGS Suite Expands Clonality and MRD Research in Lymphoid Malignancies

Lymphoid malignancies require molecular tools that can distinguish clonal immune receptor rearrangements and track disease-related sequences over time. As immune receptor measurable residual disease analysis... Read more

Hematology

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Updated Ferritin Thresholds Improve Detection of Iron Deficiency
New Automated Hemostasis Systems Become Available Across US Laboratories
Variation in AML Residual Disease Testing Prompts Push for Standardization
Image Credit: Adobe Stock

New Donor Genetic Marker May Help Predict Stem Cell Transplant Success

Donor selection for hematopoietic stem cell transplantation plays a major role in relapse risk and survival for patients with blood cancers and other blood disorders. Despite advances in genotyping, uncertainty... Read more

Immunology

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New Web-Based Platform Helps Autoimmune Laboratories Manage Testing Complexity
Routine Newborn Blood Spots Can Measure GBS Antibody Levels
Blood Test Differentiates Bacterial and Viral Infections in Febrile Infants
Image: A new single-tier diagnostic test now demonstrates potential to improve early detection by analyzing antibody responses to Borrelia burgdorferi antigens (Image Credit: Shutterstock)

Single-Tier Lyme Disease Test Shows High Sensitivity in Early Infection

Lyme disease can be difficult to diagnose during the earliest stages of infection, when conventional serologic testing may have limited sensitivity. Patients may present during a diagnostic gray zone in... Read more

Microbiology

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Nanodroplet CRISPR Technology Supports Rapid, Multiplexed Mycobacterial Identifi...
Genomic Workflow Identifies Fungal Pathogens Before Blood Cultures Turn Positive
FDA-Cleared Multiplex PCR Test Detects 13 Respiratory Pathogens in a Single Samp...
Image: Invasive aspergillosis (IA) is a potentially life-threatening infection caused by Aspergillus mold that primarily affects people with severely weakened immune systems. (Image Credit: Adobe Stock)

Rapid Urine Test Aids Diagnosis of Invasive Aspergillosis

Invasive aspergillosis is an uncommon mold infection in the general population but can pose serious risks for people with weakened immune defenses. Diagnosis can be difficult because existing approaches... Read more

Pathology

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Genomic Classifier Predicts Benefit From Adding Hormone Therapy to Salvage Prostate...
New AI Model Maps Where Glioblastoma Could Return After Surgery
Multimodal AI Supports Prostate Cancer Risk Assessment Across Diverse Cohorts
Image: Brain cancer margins can be especially difficult to map. Using mass spectrometry, researchers from Purdue University and the Mayo Clinic can map margins in resected tissue in a three-minute measurement as seen in the illustration. (Image Credit: Mahdiyeh Shahi/Purdue University)

Rapid Mass Spectrometry Test May Aid Glioma Margin Decisions

Glioma brain tumors are highly infiltrative and can extend into nearby healthy brain tissue, making tumor margins difficult to define during surgery. Residual tumor cells may contribute to recurrence and... Read more

Technology

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Laser-Enhanced Assay Boosts Sensitivity for Colorectal Cancer Biomarker Detectio...
New Automation Workflow Streamlines NGS Library Preparation for High-Volume Labs
ADLM Calls for CLIA Updates to Support Safe AI Use in Laboratory Medicine
Image: The laser-based photoacoustic spectroscopy setup consists of a Mid-IR laser equipped with three QCL modules covering wavelengths from 5.6 μm to 12.9 μm, two silver coated mirrors (SCM), a dichroic mirror (DM) with a transmittance of 90%, a thermal power sensor head (PM) to monitor the output laser power, a mechanical chopper (MC) for frequency modulation and a CEPAS-detector with a self-designed swab holder (SH). (Credit: Graunke, T., Scholz, T., Pieniak, M. et al. Scientific Reports (2026). https://doi.org/10.1038/s41598-026-68298-9)

Laser-Based Swab Analysis Shows Promise for Detecting Disease-Linked Odor Patterns

Disease-related changes in volatile organic compounds can alter body odor, producing measurable patterns in exhaled breath and bodily fluids. Current analytical methods can be complex, time-consuming,... Read more

Industry

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Expanded Partnership Supports AI Biomarker Validation and Clinical Trial Deploym...
Collaboration Combines AI Cognitive Assessment and RNA Blood Testing for Earlier...
Mayo Clinic Laboratories and Pathology Asia Expand Genomic Testing Across Asia-P...
Image: TruVerus is designed to deliver a broad menu of routine blood tests from a small blood sample on a single, automated benchtop platform (Photo courtesy of Truvian Health)

Collaboration Advances Automated Benchtop Platform for Routine Blood Testing

Routine blood testing is central to clinical decision-making, but access can vary across laboratory and healthcare settings. Broader use of automated benchtop platforms may help integrate testing more... Read more

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