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Clinical Chemistry

Image: A large, international study led by City of Hope found that the new, investigational liquid biopsy, called PANXEON, was highly sensitive in detecting stage 1 and 2 pancreatic cancer and had a low rate of false positives. The test was also able to identify high-grade dysplasia, a precancerous condition of the pancreas, potentially enabling intervention before cancer develops. (Photo courtesy of City of Hope)

Multi-Biomarker Blood Test Shows Promise for Early Pancreatic Cancer Detection

An AI-enabled multi-biomarker blood test detects early-stage pancreatic cancer (87% sensitivity) and flags high-grade dysplasia. More...
16 Sep 2026
Image Credit: Diane E. MacDougall et al., FIND Lp(a) Machine Learning Model: Targeted Screening Enrichment of Elevated Lipoprotein(a) in Atherosclerotic Cardiovascular Disease, JACC: Advances (2026). DOI: 10.1016/j.jacadv.2026.103114

Machine Learning Supports Targeted Screening for Elevated Lipoprotein(a)

An AI approach leverages EMR data to target Lp(a) screening, finding ASCVD patients over 2x likelier to have high levels. More...
16 Sep 2026
Image: Researchers from Korea University investigated whether changes in plasma p-tau217 could provide an early, minimally invasive measure of biological response to lecanemab in people with early Alzheimer’s disease (Image Credit: Prof. Sung Hoon Kang from Korea University College of Medicine)

Blood Biomarker May Help Monitor Early Response to Lecanemab in Alzheimer’s Disease

A blood-based p-tau217 test tracks early response to lecanemab and aligns with slower cognitive decline in early AD. More...
16 Sep 2026
Image: Researchers identified a naturally occurring brain-related antibody linked to lower depression and PTSD symptoms after TBI (Image Credit: Adobe Stock)

Blood Antibody Linked to Lower Depression and PTSD Symptoms After Brain Injury

New findings link higher blood levels of a brain-related antibody to reduced depression and PTSD after traumatic brain injury. More...
15 Sep 2026
Image: Using blood samples and physical measures from children as young as 8, investigators identified protein signatures that mirrored adult biomarkers linked to irreversible cardiovascular disease (Image Credit: Shutterstock)

Childhood Blood Biomarkers May Reveal Early Heart, Kidney, and Metabolic Risks

An AI-derived blood proteomic signature flags early cardio-kidney-metabolic risk in children, enabling targeted prevention. More...
15 Sep 2026
Image Credit: Adobe Stock

Blood Biomarker Study Reveals Early Signals of Future Cognitive Difficulties

New data show that a blood-based Alzheimer’s marker is linked to poorer memory six years later, supporting early risk stratification. More...
15 Sep 2026
Image: Schematic overview of the development of the Angiotensin II certified reference material. The reference material was characterized using isotope dilution mass spectrometry and the mass balance method, with an assigned value of 0.8734 g/g and a relative expanded uncertainty of 1.8% (k = 2). It remained stable for 12 months at −20 °C and is traceable to the SI unit of mass. (Photo courtesy of Yanjie Huang)

New Reference Material Aims to Improve Comparability of Angiotensin II Testing

A new reference material for angiotensin II supports method harmonization and traceable, comparable results across labs More...
15 Sep 2026
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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