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Clinical Chemistry

Illustration of CNF-sheet-mediated membrane fusion between an extracellular vesicle and a lipid nanoparticle carrying molecular beacons for internal microRNA detection. (Image Credit: Kawaguchi et al., Cell Reports Physical Science, 2026. DOI: 10.1016/j.xcrp.2026.103613)

Single-Vesicle Analysis Reveals Tissue-Associated Inflammatory Signatures

A sheet-based assay analyzes individual extracellular vesicles for RNA and surface markers to help localize tissue inflammation. More...
07 Nov 2026
Image: Longitudinal plasma proteomic profiling may help monitor immunotherapy response, detect emerging resistance, and identify disease progression before conventional imaging in advanced NSCLC. (Image Credit: Shutterstock)

Plasma Proteomic Test Detects Immunotherapy Resistance Before Imaging in Lung Cancer

A plasma proteomics-based 22-protein signature detects NSCLC immunotherapy resistance before radiologic progression. More...
07 Nov 2026
Image: Fluorescence image of water-acetone mixture condensation. (Photo courtesy of Jingcheng Ma/Interfacial Thermofluids Laboratory)

New Breath Condensate Testing Approach Enhances Reliability for COPD Monitoring

A new model of EBC sampling quantifies evaporation losses to guide standardization for reliable COPD monitoring. More...
06 Nov 2026
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Blood Protein Analysis Reveals Menopause-Associated Signals of Brain Aging

New findings identify a 16-protein blood signature of menopause that flags brain aging and signals higher dementia risk. More...
04 Nov 2026
Image: Elevated creatinine levels do not necessarily indicate impaired kidney function: pre-treatment cystatin C measurement is key to assessment (Image Credit: Data panels adapted from Watanabe H, et al. Clin Pharmacol Ther (2026). All icons were obtained from bioicons.com and modified.)

Cystatin C Testing Helps Distinguish Abemaciclib Effect from Kidney Injury

A baseline cystatin C test distinguishes abemaciclib-related creatinine rise from kidney injury, avoiding unnecessary dose cuts. More...
03 Nov 2026
Image: Researcher Joris Deelen (Photo courtesy of Elton Alisson/Agência FAPESP)

Blood-Based Score May Support Targeted Interventions for Healthier Aging

A new blood-based metabolic score using 10 routine markers predicts longevity and cardiometabolic risk. More...
03 Nov 2026
Image: Two major international studies identified noninvasive tests that can accurately diagnose and assess MASLD and MASH, reducing reliance on liver biopsy. (Image Credit: Adobe Stock)

Noninvasive Tests Offer Alternatives to Biopsy for Assessing Advanced Liver Scarring

New data identify noninvasive blood and imaging tests that detect advanced liver fibrosis and cirrhosis while reducing the need for biopsy. More...
02 Nov 2026
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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