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Clinical Chemistry

Image: Workflow of 19 F NMR–based serum amino acid profiling and data analysis. Serum samples collected from CRC patients were subjected to fluorine-labeling–based amino acid detection followed by 19 F NMR spectroscopy. Quantified amino acid data were processed using ratio-based normalization and multivariate analyses to characterize stage-specific metabolic patterns and construct machine learning models for prognostic risk prediction. (Photo courtesy of KAIST)

Preoperative Blood Test Predicts Colorectal Cancer Recurrence and Metastasis

A single preoperative blood sample may improve recurrence or metastasis prediction in colorectal cancer patients. More...
23 Jul 2026
Image: Accurately assessing LDL cholesterol is increasingly important as guidelines recommend lower treatment targets, while underestimation can lead to missed treatment opportunities (Image Credit: 123RF)

New Machine-Learning Equation Improves LDL Cholesterol Assessment

An AI approach updates a widely used LDL cholesterol calculation, improving classification in people with high triglycerides. More...
17 Jul 2026
Image: Phosphorylated tau 217 is a modified tau protein linked to cognitive decline in Alzheimer’s disease and strongly associated with beta amyloid (Photo courtesy of Adobe Stock)

Blood Biomarker May Signal Cognitive Decline Risk a Decade Before Symptoms

A blood test measuring an Alzheimer’s marker estimates long-term risk of cognitive decline in adults without symptoms. More...
16 Jul 2026
Graphical Abstract (Image Credit: Joohyung Park et al., Chemical Engineering Journal, 2026. DOI: 10.1016/j.cej.2026.179140)

Ultrasensitive Biosensor Detects Early Liver Fibrosis from Blood

A new blood test measures a key fibrosis-related marker to detect early liver fibrosis with 95% sensitivity and 100% specificity. More...
15 Jul 2026
Image: The blood-based assay analyzes amyloid beta and phosphorylated tau, brain proteins associated with Alzheimer’s disease, to support clinical diagnosis (Image Credit: Adobe Stock)

Blood Test Improves Alzheimer’s Diagnosis Across Care Settings

New data show a blood-based Alzheimer’s test boosts diagnostic accuracy in routine care, approaching specialist performance. More...
14 Jul 2026
Image Credit: Shutterstock

New Immunoassay Enables Ultrasensitive Blood-Based Tau Tangle Measurement

A new blood test detects extremely low levels of a key Alzheimer’s-related biomarker, supporting disease staging and treatment response monitoring. More...
14 Jul 2026
Image: The distinct hormone signature correctly identified more than 95% of endometriosis patients in the study, indicating potential utility for a simple, noninvasive diagnostic pathway (Image Credit: Adobe Stock)

Blood Hormone Pattern Distinguishes Endometriosis with High Accuracy

Researchers identify a blood hormone fingerprint for endometriosis, supporting noninvasive detection. More...
10 Jul 2026
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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