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Pathology

Image: The IVIS Lumina Series III Preclinical in vivo Imaging System (Photo courtesy of Perkin Elmer).

Key Genes Identified for Leukemia Development

Human leukemia is characterized by the prevalence of recurrent chromosomal translocations, resulting in the generation of chimeric fusion proteins with aberrant oncogenic activities.   More...
25 Jan 2016
Image: Clinical features of local recurrences that are defined as the reappearance of melanoma in or contiguous with an excision scar or graft and bearing an in situ component (Photo courtesy of Dr. Paola Savoia).

Blood Test Monitors DNA Fragments for Melanoma Metastases

A blood test which monitors blood levels of DNA fragments from dead cancer cells does a superior job than the current standard test at tracking the severity and potential spread of metastatic melanoma.  More...
25 Jan 2016
DIASOURCE (A Biovendor Company)
Image: Single Molecule Real-Time (SMRT) DNA sequencing technology (Photo courtesy of Pacific Biosciences).

Tissue Typing Method Revolutionizes Field of Stem Cell Transplantation

Saliva and blood samples can be typed using a new system that allows scientists to obtain very high quality information about a patient and donor's tissue types, enabling them to make the best possible matches.   More...
24 Jan 2016
Image: Histopathology of a left-ovarian mass showing a histologic picture similar to the breast carcinoma with sheets of high-grade tumor cells surrounded by a lymphoplasmacytic infiltrate. The patient had a BRAC2 gene mutation (Photo courtesy of NYU Langone School of Medicine).

Genetic Test Introduced for High-Risk Breast and Ovarian Cancer

A new 26-gene screening panel, myBRCA HiRisk is a comprehensive High-Risk Breast and Ovarian Cancer screening test specifically designed for high-risk populations has been introduced.   More...
19 Jan 2016
Image: A cell phone camera is sufficient to examine tissue samples for tumor cells (Photo courtesy of Fraunhofer IAP).

Polymer-Based Rapid Test Visually Differentiates Tumor Cells

A polymer-based rapid test has been developed which visually differentiates tumor cells from healthy cells in a tissue section through the use of a simple microscope. Surgeons can already use the test in the operating room which saves time and expenses.  More...
18 Jan 2016
Image: (a) Interferogram obtained using IPM. Sample is still barely seen. However, the OPD information is encoded into the bend of the interference fringes, as can be seen from the enlarged region of interest in (b). (c) The OPD map of the same sperm cell, as digitally calculated from the interferogram shown in (a). All the main morphological features of the cell are discernable. (c, e) Imaging of a sperm cell with an acrosomal vacuole, using: (d) label-based BFM, and (e) label-free IPM. The vacuole is clearly seen as a defect in the OPD map of the IPM image. BFM = bright-field microscopy; IPM = interferometric phase microscopy; OPD = optical path delay (Photo courtesy of Haifler M, Girshovitz P, et al., 2015, and Elsevier publications).

Improved Microscopy May Identify Best Viable Sperm Cells for Reproductive Assistance

Researchers’ cutting-edge, stain-free innovation enables more effective screening for and identification of high-quality sperm candidates for assisted reproductive technology.  More...
17 Jan 2016
Image: The Leica TCS SP8 confocal laser scanning microscope (Photo courtesy of Leica Microsystems Inc.).

Molecular Studies of Suppressor Gene Advance Understanding of Metastasis

A gene that is known to suppress the growth and spread of many types of cancer has the opposite effect in some forms of colorectal cancer and these findings may lay the foundation for new colorectal cancer treatments.  More...
17 Jan 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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