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Image: Schematic diagram of the microfluidic chip platform (D.Adnan, N. R.deBarros, L. S.Santovito, et al., Advanced Science (2026). DOI: 10.1002/advs.202508934)

Tumor-on-a-Chip Platform Models Pancreatic Cancer Treatment Response

Pancreatic cancer remains one of the hardest malignancies to treat because tumors are embedded within a dense microenvironment that shapes growth and therapy response. Read more
07 May 2026 | Technology
Image: These findings suggest tumor transcriptomic errors may provide a predictive framework for personalizing treatment in metastatic kidney cancer (photo courtesy of Shutterstock)

Study Links Abnormal Gene Splicing to Treatment Response in Metastatic Kidney Cancer

Selecting effective therapy for metastatic renal cell carcinoma (mRCC) is challenging because reliable predictive biomarkers are scarce. Read more
07 May 2026 | BioResearch
Image: The dSAA method partitions a patient’s cerebrospinal fluid into nanoliter-scale compartments and digitally counts the number of TDP-43 protein “seeds” present under a microscope (image credit: Shutterstock)

Ultrasensitive Test Detects Key Biomarker of Frontotemporal Dementia Subtype

Dementia affects more than 57 million people worldwide and is projected to nearly double within two decades, straining health systems and families. Read more
06 May 2026 | Clinical Chem.
Image: SPARK overview, data structure and study design (Trost, F., Zhang, B., Aring, I. et al. https://doi.org/10.1038/s41591-026-04357-y)

AI System Analyzes Routine Pathology Slides to Predict Cancer Outcomes

The digital transformation of pathology is expanding how cancers are evaluated in routine practice. Artificial intelligence (AI) is increasingly applied to routinely collected histological tissue sections, yet many approaches face limits in interpretability and transferability to new questions. Read more
06 May 2026 | Pathology
Image: The approval enables clinical laboratories to use a validated, blood-based method to determine eligibility for the targeted therapy (photo courtesy of Guardant Health)

FDA Clears Blood-Based Companion Diagnostic for Advanced Breast Cancer Therapy

Endocrine therapy resistance remains a significant challenge in estrogen receptor–positive, human epidermal growth factor receptor 2–negative (HER2-) advanced breast cancer, where tumor evolution can limit the effectiveness of standard treatments. Read more
06 May 2026 | Industry
Image: The findings support tumor genomic testing in pituitary carcinomas and aggressive pituitary adenomas, to guide consideration of immunotherapy as a potential first-line option (photo courtesy of Adobe Stock)

Tumor Genomic Testing Guides Immunotherapy Selection in Pituitary Tumors

Aggressive pituitary tumors are rare and difficult to manage, and many cases respond poorly to surgery, radiation, and temozolomide. Read more
05 May 2026 | Molecular Diagnostics
Image: Usability assessment (Yerlikaya S, Chirwa M, Ajide B, et al.; New England Journal of Medicine (2026). DOI: 10.1056/NEJMoa2509761)

Rapid Tongue Swab Molecular Test Detects Pulmonary Tuberculosis at Point of Care

Pulmonary tuberculosis remains one of the top infectious killers worldwide, causing more than 1 million deaths and over 10 million new cases each year. Read more
05 May 2026 | Molecular Diagnostics
Image: Abstract (Tamrin SH, Sanati Nezhad A, Sen A. ACS Omega. 2025;10(50):61568–61579. doi:10.1021/acsomega.5c07331)

New Platform Captures Extracellular Vesicles for Early Cancer Detection

Early diagnosis remains the most effective way to reduce cancer mortality, yet many screening tools miss disease at its earliest stages. Read more
05 May 2026 | Technology
Image: Aplastic anemia is a rare, life-threatening condition where immune attack on blood stem cells impairs blood cell production (Photo courtesy of Shutterstock)

Research Reveals How Some Aplastic Anemia Patients Recover Bone Marrow Function

Aplastic anemia is a rare, life-threatening blood disorder caused by an autoreactive immune attack on blood stem cells, leading to failure of blood production. Read more
05 May 2026 | BioResearch
Image: The minimally invasive, cost-effective liquid biopsy offers an accessible alternative to tissue biopsy for tailoring breast cancer treatment strategies (photo credit: 123RF)

Liquid Biopsy Predicts Immunotherapy Response in Breast Cancer

Immunotherapy is now used for high-risk, early-stage breast cancer, but many tumors do not shrink and clinicians lack timely biomarkers to steer care. Read more
05 May 2026 | Molecular Diagnostics
Image: New findings show that routine blood tests performed several years before pregnancy are associated with later risk of hypertension and pre-eclampsia (photo credit: Adobe Stock)

Routine Blood Tests Years Before Pregnancy Could Identify Preeclampsia Risk

High blood pressure during pregnancy is common and can progress to pre-eclampsia, making close monitoring at antenatal visits essential. Read more
04 May 2026 | Clinical Chem.
Image: Stuart Ibsen, Ph.D., led the team that developed a new technique using an electronic jolt and nanoparticles to reveal the telltale signal of an insidious form of cancer (Photo courtesy of OHSU/Christine Torres Hicks)

New Blood Test Distinguishes Pancreatic Cancer From Benign Disease

Pancreatic cancer is often detected only after it has advanced, when therapeutic options are limited and outcomes are poor. Read more
04 May 2026 | Molecular Diagnostics
Image: Unity Confirm is a circulating fetal cell–based confirmation test designed for use following a high‑risk Unity Aneuploidy Screen result (Photo courtesy of BillionToOne)

Noninvasive Test Confirms High-Risk Prenatal Screening Results from Blood

Noninvasive prenatal screening (NIPT) is widely used to assess fetal chromosomal risk, but a high‑risk result still requires confirmation by chorionic villus sampling or amniocentesis. Read more
04 May 2026 | Molecular Diagnostics
Image: Schematic of Mpox diagnostic methods.(A) Artificial intelligence (AI)-enhanced image classification can be leveraged to classify lesions concerning for Mpox, particularly in low resource settings where specialists (i.e., infectious disease specialists or dermatologists) are not available. (B) Clinical specimens (including nasal swabs, lesion swabs, or serum samples) can be used for molecular or biochemical confirmation of Mpox infection. (C) Rapidly, field-deployable devices or assays can be developed using various strategies(Mpox) diagnostic methods (Yilgic D, Ergonul O, Tasoglu S. Mpox diagnosis at POC. Trends in Biotechnology. DOI: 0.1016/j.tibtech.2025.04.015)

Point-of-Care Tests Could Expand Access to Mpox Diagnosis

Mpox outbreaks in non-endemic regions have underscored the need for rapid, accessible diagnostics to limit transmission. Read more
04 May 2026 | Immunology

Channels

Clinical Chemistry

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Routine Blood Tests Identify Biomarkers Linked to PTSD
Proteomic Data Underscore Need for Age-Specific Pediatric Reference Ranges
Routine Blood Count Ratio Linked to Future Alzheimer’s and Dementia Risk
Image: The blood test uses an immune-profiling method to detect germ cell tumors, the most common form of testicular cancer (photo credit: Adobe Stock)

Blood Test Detects Testicular Cancer Missed by Standard Markers

Testicular cancer most often affects adolescents and young adults and is highly treatable when found early. Diagnosis can be difficult when tumors do not produce sufficient levels of standard blood-based... Read more

Molecular Diagnostics

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Genomic Classifiers Improve Risk Stratification and Treatment Selection in Urologic...
CRISPR-Based Test Identifies Multiple Respiratory Viruses Simultaneously
Multi-Omic Assay Predicts Recurrence and Radiation Benefit in Early Breast Cance...
Image: A machine learning tool, T1GRS, accurately predicts genetic risk of type 1 diabetes in children and adults (Photo courtesy of Adobe Stock)

Machine-Learning Genetic Risk Score Improves Early Prediction of Type 1 Diabetes

Type 1 diabetes develops when autoimmune destruction of pancreatic cells stops insulin production, leaving patients dependent on lifelong insulin therapy. Predicting who will develop the disease remains... Read more

Hematology

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Blood Test Enables Early Detection of Multiple Myeloma Relapse
Single Assay Enables Rapid HLA and ABO Genotyping for Transplant Matching
Prognostic Biomarker Identified in Diffuse Large B-Cell Lymphoma
Image: The indices are presented through intuitive software on the Aquila, Aquarius 3, and Abacus 5 analyzers (photo courtesy of Diatron)

Advanced CBC-Derived Indices Integrated into Hematology Platforms

Diatron, a STRATEC brand, has introduced six advanced hematological indices on its Aquila, Aquarius 3, and Abacus 5 hematology analyzers. The new Research Use Only (RUO) indices include Neutrophil-to-Lymphocyte... Read more

Immunology

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Finger-Prick Lateral Flow Test Detects Sepsis Biomarkers at Point of Care
Study Highlights Low Sensitivity of Current Lyme Tests in Early Infection
Immune Aging Clock Quantifies Immunosenescence and Identifies Therapeutic Target
Image: Graphical abstract (Turano PS, Akbulut E, Dewald HK, et al. Cell Reports (2026). DOI: 10.1016/j.celrep.2025.116795)

T-Cell Senescence Profiling May Predict CAR T Responses

Chimeric antigen receptor (CAR) T-cell therapy can deliver striking, durable remissions, yet many patients experience minimal or no benefit. The quality of patient-derived cytotoxic T lymphocytes used... Read more

Microbiology

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Oral–Gut Microbiome Signatures Identify Early Gastric Cancer
Label-Free Microscopy Method Enables Faster, Quantitative Detection of Malaria
Gut Microbiome Test Predicts Melanoma Recurrence After Surgery
Image: Biosensor for tuberculosis detection (photo courtesy of UPV)

Rapid Antigen Biosensor Detects Active Tuberculosis in One Hour

Tuberculosis remains a major global health challenge and continues to drive significant morbidity and mortality. The World Health Organization’s 2024 global report cites it as the leading cause of death... Read more

Pathology

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Multimodal AI Tool Predicts Genetic Alterations to Guide Breast Cancer Treatment
Interpretable AI Reveals Hidden Cellular Features from Microscopy Images
Tumor Immune Structure Predicts Response to Immunotherapy in Melanoma
Image: The researchers derived a gene-based signature and a blood test to help identify this high-risk subgroup (photo credit: Shutterstock)

New Tissue Mapping Approach Identifies High-Risk Form of Diabetic Kidney Disease

Diabetic kidney disease is a leading cause of chronic kidney disease and end-stage kidney disease, affecting 20%–40% of people with diabetes and more than 107 million individuals worldwide as of 2021.... Read more

Technology

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AI Tool Predicts Non-Response to Targeted Therapy in Colorectal Cancer
Integrated System Streamlines Pre-Analytical Workflow for Molecular Testing
Noninvasive Sputum Test Detects Early Lung Cancer
Image: The MechanoAge platform, shown here on a microscope stage, could be used to detect breast cancer risk. (Photo courtesy of Adam Lau/Berkeley Engineering)

Microfluidic Single-Cell Assay Predicts Breast Cancer Risk

Risk stratification for breast cancer remains imprecise, as population-based models and breast density can over- or underestimate individual risk, potentially leading to over- or under-screening.... Read more

Industry

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Thermo Fisher Scientific to Sell Microbiology Business to Astorg
Collaboration Expands Access to Rapid Metagenomic Diagnostics for Complex Infect...
QuidelOrtho Adds Ultra-Fast PCR Platform with LEX Acquisition
Image: CareDx entered an agreement to acquire Naveris for $160 million upfront, with up to $100 million in additional milestone payments.

CareDx Expands Precision Oncology Portfolio with Naveris Acquisition

CareDx Inc. (Brisbane, CA, USA), a precision medicine company advancing clinically differentiated, high-value healthcare solutions for transplant patients and caregivers, has entered a definitive agreement... Read more

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