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Respiratory Tract Bacterium Triggers Serious Nervous System Disease

Guillain-Barré syndrome (GBS) is an acute post infectious immune-mediated polyneuropathy and an acute life-threatening disease of the nervous system that leads to sensory disturbances and acute flaccid paralysis. More...
20 Oct 2016
Image: A photomicrograph of Prion Protein immunostaining from a biopsy in a patient with variant Creutzfeldt-Jakob Disease (Photo courtesy of SPL).

Urine Test Could Diagnose Sporadic Creutzfeldt-Jakob Disease

Prions are infectious agents that cause invariably fatal brain diseases such as Creutzfeldt-Jakob Disease (CJD) in humans, scrapie in sheep and bovine spongiform encephalopathy (BSE or 'mad cow disease') in cattle. More...
20 Oct 2016
Mayo Medical Laboratories
Image: Immuno-wall chips with the photo reactive polymer in the center of the 40 microchannels are made with a biotinylated anti-R132H-IDH1 antibody (HMab-2), an anti-wild-type IDH1 antibody (RcMab-1), and fluorescent antibodies. It shows sensitive and specific fluorescence from mutant IDH1 (Photo courtesy of Nagoya University).

Novel Device Enables Rapid Identification of Brain Cancer Type

A device has been developed for quick, accurate identification of a mutation strongly associated with a cancer that affects the central nervous system, potentially enabling accurate removal of the entire tumor during an operation. More...
20 Oct 2016

Liquid Biopsy Tests Identified Cell-Free Tumor DNA Mutations

The feasibility of using cell-free circulating tumor DNA (ctDNA) next-generation sequencing (NGS) from liquid biopsies as a complement or alternative to tissue NGS has been evaluated. More...
20 Oct 2016
Image: A histopathology of non-alcoholic steatohepatitis (NASH) in a liver biopsy (Photo courtesy of SPL).

Simple Blood Test Vastly Improves Severe Liver Disease Detection

A new non-invasive method of predicting the risk of developing a severe form of liver disease could ensure patients receive early and potentially life-saving medical intervention before irreversible damage is done. More...
19 Oct 2016

Unnecessary Endoscopies Could Be Avoided with Fecal Blood Test

The majority of primary care patients referred for bowel endoscopy do not have significant colorectal disease (SCD), and are unnecessarily exposed to a small but realistic risk of severe endoscopy-associated complications. More...
14 Oct 2016
Image: An experiment examining retina tissue for mHtt deposition in GFAP-ir astrocytes in R6/2 mouse model of Huntington’s Disease. Green: glial fibrillary acidic protein (GFAP); Red: mutant huntingtin protein (mHtt). (A) A low magnification picture illustrates GFAP-ir astrocytes and mHtt deposits from the retinal wholemount of 12-week-old R6/2 (Huntington’s disease model) mouse. Scale bar = 50 µm. (B) A detailed confocal analysis of GFAP positivity, mHtt immunoreactivity, and DAPI counterstain (blue) revealed no colocalization of GFAP and mHtt. Scale bar = 20 µm (Image courtesy of PLoS One).

Changes in Eye Tissue May Enable Early Detection of Brain Diseases

Research with mouse models has shown that at least some diseases of the central nervous system (CNS) manifest as pathological changes in the retina of the eye and that these changes may be detected earlier than brain changes. The findings suggest that eye examination could be used for minimally invasive screening for these diseases. More...
11 Oct 2016

The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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