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Pathology

Image: An IsoPSA test for prostate cancer detection and differentiation (Photo courtesy of Dr. Arnon Chait, PhD).

Novel Test Differentiates Malignant Prostate Cancer Grades

A promising new test has been introduced that detects prostate cancer more precisely than current tests, by identifying molecular changes in the prostate specific antigen (PSA) protein and can also differentiate between high-risk and low-risk disease, as well as benign conditions. More...
25 May 2016

Potential Noninvasive Biomarker of EoE Disease Activity Identified

Researchers have identified a potential blood-based marker of disease activity for the severe and often painful food allergic disease eosinophilic esophagitis (EoE) – possibly leading to a blood test, which could spare EoE patients, often children, the discomfort and risk of the currently used invasive endoscopic monitoring procedures. More...
24 May 2016

Innovative Gene Testing Technology Finds Cancer Risks

A new method has been developed for identifying mutations and prioritizing variants in breast and ovarian cancer genes, which will not only reduce the number of possible variants for doctors to investigate, but also increase the number of patients that are properly diagnosed. More...
19 May 2016
Image: A photomicrograph of an abnormal Pap smear showing changes consistent with Human Papilloma Virus (HPV) and Mild Dysplasia. Note the irregular perinuclear cytoplasmic clearing, which is the key characteristic of identifying HPV visually on a Pap smear (Photo courtesy of Dr. Cynthia D Booth, MD).

Combining Two Diagnostic Tests Drastically Reduces Cancer Miss Rates

The Papanicolaou (Pap) test is recommended for women between 21 and 65 years old as a screening test for cervical cancer. Women 30 and older who are negative on co-testing may wait as long as five years for their next testing, but physicians still recommend annual examinations. More...
17 May 2016

Study Finds Excessive Testing Prescribed for Monoclonal Gammopathy Patients

A retrospective analysis has determined that the tests for M-protein that physicians routinely order to help diagnose and monitor patients with the age-related immune disorder monoclonal gammopathy (MG), often do not benefit the patient. Pathologists who performed the study have proposed an optimizing algorithm for more effective decision-making based on the evidence for clinical value. More...
17 May 2016
Image: A histologic view of an endometrial adenocarcinoma showing many abnormal nuclei (Photo courtesy of Wikimedia Commons).

Study Finds Five New Genetic Risk Loci for Endometrial Cancer

Genome-wide association studies (GWAS) have revealed five previously unknown risk loci for endometrial cancer. More...
16 May 2016
Image: A structural model of the Bim protein (Photo courtesy of Wikimedia Commons).

Levels of Bim Protein in T-cells Reflect Success of Anti–PD-1 Cancer Therapy

Measurement of levels of Bim (BCL-2-interacting mediator of cell death) protein in circulating T-cells of cancer patients may provide a less invasive strategy to predict and monitor responses to anti–PD-1 therapy. More...
16 May 2016


The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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