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Pathology

Image: Micrograph of a phyllodes tumor (right of image) with the characteristic long clefts and myxoid cellular stroma. Normal breast and fibrocystic change are also seen (left of image) (Photo courtesy of Wikimedia Commons).

Biomarker Panel Characterizes Rare Phyllodes Breast Tumors

Cancer researchers have established a panel of biomarkers that characterizes the rare phyllodes form of breast tumors.  More...
28 Jan 2015
Image: Illustration of a normal heart compared to a heart with dilated cardiomyopathy (Photo courtesy of Blausen Gallery 2014. Wikiversity Journal of Medicine).

Sequencing Study Links Mutations in Major Heart Muscle Protein to Development of Dilated Cardiomyopathy

British heart disease researchers using advanced gene sequencing techniques have identified mutations in the TTN gene, which encodes the muscle protein titin, linked to development of dilated cardiomyopathy that are different from benign mutations in this gene that are carried by a large percentage of the population.  More...
27 Jan 2015
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Image: The ABI 7500 HT real-time polymerase chain reaction system (Photo courtesy of Applied Biosystems).

New Gene Identified That Drives Triple-Negative Breast Cancer

A novel gene has been discovered that, when mutated, can drive development and progression of triple-negative breast cancer which is an aggressive form of the disease that accounts for 10% to 20% of breast cancers.  More...
26 Jan 2015
Image: Schematics of the basis of the NuQ assays: A nucleosome is a section of DNA that is wrapped around a core of proteins. DNA is compacted as protein complexes in a “beads on a string” structure (Photo courtesy of VolitionRx Limited).

Blood Test Detects Early Stage Treatable Pancreatic Cancers

A recent clinical study has demonstrated that a blood-based diagnostic platform is able to accurately detect 84% of early, surgically-treatable pancreatic cancers with a high 92% specificity.   More...
21 Jan 2015

Heart Failure Patients’ Blood Glucose Levels Predict Mortality Risk

The prognostic implications of blood glucose on a wide range of outcomes including early mortality, hospitalizations, and incident diabetes diagnoses have not been fully elucidated in acute heart failure syndromes.  More...
19 Jan 2015

Data Reinforce HPV as First-Line Test in Cervical Cancer Screening

Newly published data from a 3-year trial support new, interim professional guidance from medical societies on use of human papillomavirus as a first-line test in cervical cancer screening for women from age 25.   More...
19 Jan 2015
Image: Biopsy slide of a classic tubular adenoma polyp that is precancerous (Photo courtesy of Dr. Scot M. Lewey).

Fecal Occult Blood Screening Increases High-Risk Polyp Detection

The introduction of biennial colorectal cancer screening in a region of France increased the rate of diagnosis of high risk precancerous adenomas, sometimes called polyps, by 89%.  More...
13 Jan 2015


The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
 

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