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Pathology

Image: The Cologuard testing kit for colorectal cancer (Photo courtesy of Exact Sciences).

Noninvasive Test Detects Colorectal Cancer in Unscreened Patients

A noninvasive colorectal cancer-screening test detected the disease in patients who had previously avoided more invasive screening measures. Colorectal cancer is the second deadliest form of cancer in the USA and this year, nearly 135,000 Americans will be diagnosed with the disease and 50,000 Americans will die of it. More...
03 May 2016

Patterns of MicroRNA Expression Distinguish Patients with Asthma and Allergic Rhinitis

Subsets of circulating micro RNAs (miRNAs) are uniquely expressed in asthmatic patients and in patients with allergic rhinitis (AR) and have potential for use as noninvasive biomarkers to diagnose and characterize these diseases. More...
29 Apr 2016
Image: Immunostaining: the black fiber is positive for alpha-synuclein pathology inside a nerve fiber in the submandibular gland (Photo courtesy of Journal of Parkinson\'s Disease).

Tissue Biomarker Identified For Dementia With Lewy Bodies

Accurate diagnosis of Parkinson's disease, and the related disease "dementia with Lewy bodies," can be difficult in the early stages of both conditions. While brain biopsies can be more accurate, the risk of complications has been considered too high. More...
29 Apr 2016
Image: The Benchmark Ultra IHC/ISH staining instrument (Photo courtesy of Ventana Medical Systems).

Genetic Link Confirmed Between DCIS And Invasive Disease

Inherited genetic links have been confirmed between non-invasive cancerous changes found in the milk ducts, known as ductal carcinoma in situ (DCIS) and the development of invasive breast cancer, meaning that a family history of DCIS could be as important to assessing a woman's risk as a history of invasive breast cancer. More...
28 Apr 2016
Image: The Pyromark Q96 MD pyrosequencing instrument (Photo courtesy of Qiagen).

DNA-Based Test Determines Degree Of Liver Fibrosis

Non-alcoholic fatty liver disease (NAFLD) accounts for the majority of liver disease burden in the Western world. Liver biopsy remains the gold standard test to accurately stage fibrosis in patients with NAFLD, but it is invasive and carries risks. More...
28 Apr 2016

Study Identifies Mechanism Underlying a Form of Sensory Nerve Damage

Researchers have discovered a mechanism that underlies induction of peripheral neuropathy (PN) by the chemotherapeutic agent paclitaxel, raising the prospects for developing treatments for this and possibly also for certain other forms of PN. The work may also lead to companion diagnostics to identify patients who would benefit from these new therapies. More...
27 Apr 2016
In healthy breast tissue, the percentage of cells expressing molecular marker Ki67 (green) and p27 (red) was low (Photo courtesy of Sung Jin Huh, Harvard Medical School).

Biomarker Predicts Breast Cancer Risk in Asymptomatic Women

A biomarker has been identified that may allow clinicians to predict the risk of an asymptomatic woman eventually developing breast cancer. More...
18 Apr 2016


The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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