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Serologic Diagnostic Tests Evaluated for Chikungunya Virus

The disease caused by the mosquito borne Chikungunya virus is clinically characterized by sudden-onset fever and severe arthralgia, which may persist for weeks, months, or years after the acute phase of the infection.   More...
04 Dec 2014
Image:  Diagram of pathological changes in a glomerulus (visible via electron microscopy) in membranous nephropathy.  Black - immune complex; Dark Purple - basement membrane; Pink – endothelium; Green - visceral epithelium; Light Purple - mesangial cells (Photo by M. Komorniczak and Huckfinne, courtesy of Wikimedia).

Second Protein Identified for Common Kidney Failure

An international team of researchers has found a second protein, THSD7A, associated with a common form of kidney failure—the autoimmune “membranous nephropathy.” The discovery is likely to provide an important new biomarker for the disease.  More...
02 Dec 2014
DiagCor Bioscience
Image: Histopathology of ovarian serous papillary borderline tumor, intracystic, without surface cortical involvement (Photo courtesy of Brown University).

Prognostic Biomarker Candidates Identified for Ovarian Cancer

Two independent classes of novel candidate prognostic markers for ovarian cancer have been identified advancing efforts to develop targeted therapies for the disease.  More...
26 Nov 2014

Prognostic Biomarker Found for Post-Chemotherapeutic Relapse in Visceral Leishmaniasis

The effective clinical management, chemotherapy and control of the transmission of visceral leishmaniasis are largely dependent on early and unequivocal diagnosis as without effective chemotherapy symptomatic VL is usually fatal.  More...
06 Nov 2014
Image: Immunohistochemistry of lung tissue positive for anaplastic lymphoma kinase in non-small-cell lung cancer (Photo courtesy of Ventana Medical Systems).

Anaplastic Lymphoma Kinase Immunohistochemistry Compares with FISH Testing

The detection of anaplastic lymphoma kinase-gene rearrangements in non–small-cell lung cancer is mainly performed by fluorescence in situ hybridization.  More...
06 Nov 2014
Sekisui Diagnostics
Image: PAR Cyflow-Space Software (Photo courtesy of Sysmex PARTEC)

Flow Cytometry Rapidly Determines Specific Interleukin-6 Activity

The measurement of the specific activity of a given cytokine often requires a time-consuming and tedious bioassay based upon its effect on the proliferation, chemotaxis, or toxicity of a factor-dependent cell line.  More...
30 Oct 2014
Image: Immunofluorescence staining pattern of ANCA using FITC conjugate demonstrates presence of antineutrophil cytoplasmic antibodies (ANCA). Top left - PR3 antibodies on ethanol-fixed neutrophils showing a cytoplasmic ANCA pattern. Bottom left - PR3 antibodies on formalin-fixed neutrophils showing a cytoplasmic ANCA pattern. Top right - MPO antibodies on ethanol-fixed neutrophils showing a perinuclear ANCA pattern. Bottom right - MPO antibodies on formalin-fixed neutrophils showing a cytoplasmic ANCA pattern (Photo courtesy of  Wikimedia Commons).

Monitoring ANCA Levels Helps Predict Relapse of Systemic Vasculitis in Patients with Kidney Involvement

Repeated measurement of levels of anti-neutrophil cytoplasmic antibodies predicts likelihood of relapse in patients suffering from systemic vasculitis with kidney involvement.  More...
29 Oct 2014

The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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