Features | Partner Sites | Information | LinkXpress
Sign In
FOCUS DIAGNOSTICS, INC.
RANDOX LABORATORIES
GLOBETECH PUBLISHING

Thyroid Lesions Examined by Scanning Acoustic Microscope

By Labmedica International staff writers
Posted on 05 Mar 2014
Image: The scanning acoustic microscope AMS-50SI system (Photo courtesy of Honda Electronics Co, Ltd).
Image: The scanning acoustic microscope AMS-50SI system (Photo courtesy of Honda Electronics Co, Ltd).
A scanning acoustic microscope (SAM) uses ultrasound to image an object by plotting the speed-of-sound (SOS) through tissues on screen, and because hard tissues result in great SOS, SAM can provide data on the tissue elasticity.

Scanning acoustic microscopy uses ultrasound at 120 MHz with almost the same resolution of approximately 12.5 μm as the low magnification of a light microscope (LM), and it had been found useful in generating useful information on the lung, stomach, and lymph node lesions.

Scientists at Hamamatsu University School of Medicine (Japan) selected and examined formalin-fixed, paraffin-embedded blocks that were flat-sectioned in 10 μm thick sections from patients with inflammatory non-neoplastic and neoplastic thyroid lesions. Specimens were randomly selected from the computer database of pathological sections and typical lesions of thyroid diseases were identified based on hematoxylin and eosin sections.

The formalin-fixed, paraffin sections were scanned with a 120 MHz transducer using the SAM model AMS-50AI (Honda Electronics Co, Ltd; Toyohashi, Japan). SOS through each area was calculated and plotted on the screen to provide histological images, and SOS of each lesion was compared and statistically analyzed.

High-concentrated colloids, red blood cells, and collagen fibers showed pronounced SOS while low-concentrated colloids, parathyroids, lymph follicles, and epithelial tissues including carcinomas demonstrated lower SOS. SAM clearly discriminated structure of thyroid components corresponding to low magnification of light microscopy. Thyroid tumors were classified into three groups by average SOS: the fast group consisted of follicular adenomas/carcinomas and malignant lymphomas; the slow group contained poorly differentiated/undifferentiated carcinomas; and the intermediate group comprised papillary/medullary carcinomas.

The authors concluded that SAM imaging has the following benefits: precise images were acquired in a few minutes without special staining; structural irregularity and desmoplastic reactions, which indicated malignancy, were detected; images reflected tissue elasticity, which was statistically comparable among lesions by SOS; and tumor classification was predictable by SOS because more poorly differentiated carcinomas had a tendency to show lower SOS. The study was published on February 11, 2014, in the journal Pathology and Laboratory Medicine International.

Related Links:

Hamamatsu University School of Medicine 
Honda Electronics Co, Ltd 



Sekisui Diagnostics
DiagCor Bioscience
VIRCELL
comments powered by Disqus
Life Technologies

Channels

Clinical Chemistry

view channel
Image: The URiSCAN Super Plus reflectance meter (Photo courtesy of YD Diagnostics).

Semiquantitative Urine Dipstick Evaluated for Microalbuminuria Screening

The urine microalbumin test is used as a screening test for the diagnosis of renal complications in diseases, such as diabetic nephropathy, cardiovascular disease, and hypertension. A urine dipstick... Read more

Microbiology

view channel
Image: The adult free-living female Strongyloides stercoralis with a row of eggs within the body of the nematode (Photo courtesy of the CDC - Centers for Disease Control and Prevention).

Rapid Serological Assay Developed for Strongyloidiasis

Several imperfect methods exist for diagnosing strongyloidiasis and stool examination with microscopic identification of larvae considered the gold standard diagnostic procedure, showing good specificity... Read more

Pathology

view channel
Image: The BD Viper LT System for fully automated, integrated molecular testing on a table top analyzer (Photo courtesy of BD Diagnostics).

Modern Methods Accurately Detects Cervical Cancer

The newer Papanicolaou test (Pap tests) and human papilloma virus (HPV) screening more accurately identify precancerous cellular changes that potentially develop into cervical cancer. Compared to a... Read more

Industry News

view channel

Social Diagnostics Start-Up to Provide Simple, Affordable Tests Worldwide

The Royal Tropical Institute (KIT; Amsterdam, Netherlands) is establishing a nonprofit, social diagnostics company that develops and markets tests for the diagnosis of poverty-related diseases. Infectious diseases have a global impact; they take no account of national borders and influence the stability of societies... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.