We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Test Identifies Risk of Developing Lymphoma

By LabMedica International staff writers
Posted on 17 Feb 2014
The immune system is responsible for eliminating potentially cancerous immune B-cells in their early stages, before they developed into B-cell lymphomas, also known as non-Hodgkin's lymphomas.

Immune cells undergo spontaneous changes on a daily basis that could lead to cancers if not for the diligent surveillance of the immune system and this immune surveillance accounts for the surprising rarity of B-cell lymphomas in the population, given how often these spontaneous changes occur.

Scientists at Walter and Eliza Hall Institute (Melbourne, Australia) discovered that the loss of function of the tumor suppressor gene PR Domain Containing 1, with ZNF Domain (PRDM1), also known as B-Lymphocyte-Induced Maturation Protein (BLIMP1) or deregulated expression of the oncogene B-Cell CLL/Lymphoma 6 (BCL6), occurs in a large proportion of diffuse large B-cell lymphoma (DLBCL) cases.

Targeted mutation of either gene in a rodent model leads to only slow and infrequent development of malignant lymphoma and despite frequent mutation of BCL6 in activated B- cells of healthy individuals, lymphoma development is rare. More...
The scientists found that T-cells prevent the development of overt lymphoma, and impairment of T-cell control results in rapid development of DLBCL-like disease, which can be eradicated by polyclonal cluster of differentiation 8 (CD8+) T-cells in a T-cell receptor, CD28-dependent and Fas ligand-dependent manner.

David Tarlinton, PhD, a coauthor of the study, said, “In the majority of patients, the first sign that something is wrong is finding an established tumor, which in many cases is difficult to treat. Now that we know B-cell lymphoma is suppressed by the immune system, we could use this information to develop a diagnostic test that identifies people in early stages of this disease, before tumors develop and they progress to cancer. There are already therapies that could remove these 'aberrant' B-cells in at-risk patients, so once a test is developed it can be rapidly moved towards clinical use.” The study was published on February 2, 2014, in the journal Nature Medicine.

Related Links:

Walter and Eliza Hall Institute
 


New
Gold Member
Latex Test
SLE-Latex Test
Serological Pipet Controller
PIPETBOY GENIUS
New
Integrated Biochemical & Immunological System
Biolumi CX8
New
Automated PCR Setup
ESTREAM
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Molecular Diagnostics

view channel
Image: The RNA-seq based diagnostic test for pediatric leukemia ensures better outcomes for children with this common cancer (Photo courtesy of Qlucore)

RNA-Seq Based Diagnostic Test Enhances Diagnostic Accuracy of Pediatric Leukemia

A new unique test is set to reshape the way Acute Lymphoblastic Leukemia (BCP-ALL) samples can be analyzed. Qlucore (Lund, Sweden) has launched the first CE-marked RNA-seq based diagnostic test for pediatric... Read more

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.