Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
RANDOX LABORATORIES
FOCUS DIAGNOSTICS, INC.

New Gene Linked to Key Heart Attack Risk Factor

By Labmedica International staff writers
Posted on 26 Mar 2014
Image: Illumina HiSeq 2500 ultra-high-throughput sequencing system (Photo courtesy of Konrad Förstner).
Image: Illumina HiSeq 2500 ultra-high-throughput sequencing system (Photo courtesy of Konrad Förstner).
A previously unrecognized gene variation that makes humans have healthier blood lipid levels and reduced risk of heart attacks has been found.

The region of DNA where it was located had been implicated as being important in controlling blood lipid levels, but although this DNA region had many genes, none of them had any obvious link to blood lipid levels.

A team of scientists from the University of Michigan (Ann Arbor, Michigan, USA) and the Norwegian University of Science and Technology (Levanger, Norway) scanned the genetic information available from a biobank of a large number of Norwegians, focusing on variations in genes that change the way proteins function. Most of what they found turned out to be already known to affect cholesterol levels and other blood lipids. Total cholesterol (TC), high density lipid (HDL) cholesterol and triglycerides were measured by an enzymatic colorimetric method using the 911 Auto-Analyzer (Hitachi; Tokyo, Japan).

Genotyping of 5,771 individuals was performed using the Human Exome BeadChips (Illumina; San Diego, CA, USA) using their Infinium HD ultra protocol. The exome array includes 247,870 markers focused on protein-altering variants. Low-pass whole-genome sequencing was performed with exome enrichment on 76 cases with myocardial infarction (MI) and 76 controls using Illumina’s Hi-Seq 2500 ultra-high-throughput sequencing system. In a minority of the Norwegians who carried a particular change in a gene, blood lipid levels were much healthier and they had a lower rate of heart attack. This gene, known as Transmembrane 6 Superfamily Member 2 (TM6SF2), may also be involved in regulating lipid levels in the liver.

Cristen Willer, PhD, the senior author of the paper, said, “Cardiovascular disease presents such a huge impact on people's lives that we should leave no stone unturned in the search for the genes that cause heart attack. While genetic studies that focused on common variations may explain as much as 30% of the genetic component of lipid disorders, we still don't know where the rest of the genetic risk comes from. This approach of focusing on protein-changing variation may help us zero in on new genes faster.” The study was published on March 16, 2014, in the journal Nature Genetics.

Related Links:

University of Michigan
Norwegian University of Science and Technology
Illumina



VIRCELL
Sekisui Diagnostics
DiagCor Bioscience
comments powered by Disqus
Life Technologies

Channels

Immunology

view channel
Image: The fluorescence-activated cell sorting FACSCanto II flow cytometer (Photo courtesy of BD Biosystems).

Flow Cytometry Detects Lymphoproliferative Disorders in Fluid Specimens

Immunophenotypic analysis of hematopoietic cell populations by flow cytometry has emerged as a useful ancillary study in the diagnostic evaluation of serous effusions and cerebrospinal fluids (CSFs).... Read more

Pathology

view channel
Image: Histopathology of increased endomysial connective tissue from a patient with Duchenne Muscular Dystrophy. Necrotic fibers arrowed (Photo courtesy of Washington University in St. Louis).

New Partnership Designed to Automate Dystrophin Measurement

A developer of innovative ribonucleic acid (RNA)-based therapeutics, Sarepta Therapeutics, Inc. ( Cambridge, MA, USA), and a leading tissue-based companion diagnostics firm, Flagship Biosciences LLC (Boulder,... Read more

Lab Tech.

view channel
Image: A technical breakthrough for DNA imaging has been achieved that should quicken diagnosis of diseases for which analysis of DNA from single-cells is critical, such as early stage cancers and various pre-natal conditions (Photo courtesy of McGill University and Génome Québec Innovation Center).

Breakthrough DNA Analysis Technology to Hasten Problem Diagnosis

Researchers have achieved a technical breakthrough that should result in speedier diagnosis of diseases for which analysis of DNA from single-cells is critical, such as early stage cancers and various... Read more

Industry News

view channel

Most IVD Sector Companies Look Outside the EU and USA for Growth

Kalorama Information (New York City, NY, USA) has now published the 9th edition of its biennial market research report “Worldwide Market for In Vitro Diagnostics,” revealing estimates from its survey of the in vitro diagnostics (IVD) industry – presenting the trends, technologies, customer needs, and major suppliers with... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.